Correction: Correction: A Novel Rhabdovirus Associated with Acute Hemorrhagic Fever in Central Africa
| Autor: | Bradley S. Schneider, Jean Jacques Muyembe, Eric Delwart, Travis Taylor, J. Graham Ruby, Anne W. Rimoin, Eric M. Leroy, Deanna Lee, Taylor Sittler, Prime Mulembakani, Nathan D. Wolfe, Imke Steffen, Graham Simmons, Narayanan Veeraraghavan, Maria Makuwa, Gilda Grard, Robert B. Tesh, Jonna A. K. Mazet, Chunlin Wang, Joseph N. Fair, Elizabeth Slikas, Charles Y. Chiu |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
lcsh:Immunologic diseases. Allergy
0301 basic medicine Adult Male Hemorrhagic Fevers Viral Adolescent Immunology Molecular Sequence Data Genome Viral Antibodies Viral Microbiology Disease Outbreaks 03 medical and health sciences Mice Virology Rhabdoviridae Infections Genetics Animals Humans lcsh:QH301-705.5 Molecular Biology Phylogeny Published Erratum Philosophy Central africa Correction High-Throughput Nucleotide Sequencing 030104 developmental biology lcsh:Biology (General) Medical Microbiology Democratic Republic of the Congo Parasitology Female Rhabdoviridae lcsh:RC581-607 Humanities |
| Zdroj: | PLoS Pathogens PLoS pathogens, vol 13, iss 9 PLoS Pathogens, Vol 13, Iss 9, p e1006583 (2017) |
| ISSN: | 1553-7374 1553-7366 |
| Popis: | Deep sequencing was used to discover a novel rhabdovirus (Bas-Congo virus, or BASV) associated with a 2009 outbreak of 3 human cases of acute hemorrhagic fever in Mangala village, Democratic Republic of Congo (DRC), Africa. The cases, presenting over a 3-week period, were characterized by abrupt disease onset, high fever, mucosal hemorrhage, and, in two patients, death within 3 days. BASV was detected in an acute serum sample from the lone survivor at a concentration of 1.09 × 10(6) RNA copies/mL, and 98.2% of the genome was subsequently de novo assembled from ≈ 140 million sequence reads. Phylogenetic analysis revealed that BASV is highly divergent and shares less than 34% amino acid identity with any other rhabdovirus. High convalescent neutralizing antibody titers of1:1000 were detected in the survivor and an asymptomatic nurse directly caring for him, both of whom were health care workers, suggesting the potential for human-to-human transmission of BASV. The natural animal reservoir host or arthropod vector and precise mode of transmission for the virus remain unclear. BASV is an emerging human pathogen associated with acute hemorrhagic fever in Africa. |
| Databáze: | OpenAIRE |
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