Hepatitis C virus infection reduces the lifespan of chimpanzees used in biomedical research
| Autor: | Satoshi Hirata, Kristin Havercamp, Yumi Yamanashi, Toshifumi Udono |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Biology Letters. 18 |
| ISSN: | 1744-957X |
| DOI: | 10.1098/rsbl.2022.0048 |
| Popis: | Chimpanzees were used in hepatitis research for over three decades with the aim to identify and develop treatments for the virus, a leading cause of chronic liver disease in humans. We used a dataset of 120 chimpanzees housed at a single institution in Japan, 22 of whom became chronically infected with hepatitis C virus (HCV), to examine whether HCV infection results in a reduced lifespan as reported in humans. Survival analysis showed that HCV carriers experienced a higher mortality risk compared with non-carriers. Although no chimpanzee died from hepatic disease, carriers showed higher gamma-glutamyl transpeptidase (γGTP) levels compared with non-carriers suggesting that HCV infection negatively affected their liver condition. These results provide evidence that special attention is necessary to monitor the long-term condition of ex-biomedical primates. チンパンジーの肝炎感染実験の影響 --寿命が短くなり肝臓や腎臓に障害. 京都大学プレスリリース. 2022-08-10. |
| Databáze: | OpenAIRE |
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