Histomorphometric study of the enhancement of renal compensatory hypertrophy by ACTH in the rat
| Autor: | P. Reville, A. Stahl, F de Laharpe, J. Le Minor, C. Parmentier, M H Köll-Back, J. Turlot, F Stephan |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
medicine.medical_specialty
Endocrinology Diabetes and Metabolism medicine.medical_treatment Clinical Biochemistry Kidney Glomerulus Peptide hormone Kidney Biochemistry Nephrectomy Epithelium Muscle hypertrophy Kidney Tubules Proximal Endocrinology Adrenocorticotropic Hormone Internal medicine Medicine Animals business.industry Biochemistry (medical) Biological activity Rats Inbred Strains General Medicine Hypertrophy Organ Size Rats medicine.anatomical_structure Proximal tubule Female Compensatory hypertrophy medicine.symptom business Weight gain |
| Zdroj: | Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. 16(7) |
| ISSN: | 0018-5043 |
| Popis: | In the female adult rat, renal compensatory hypertrophy is greatly enhanced by hyperadrenocorticism elicited by the administration of ACTH given at a dose of 18 Y/100 g BW/d for 7 days after uninephrectomy (UN). This renotrophic effect of ACTH is particularly prominent in rats drinking a NaCl solution (9 g/l). In the present experiments, we performed histomorphometrical measurements of the glomerular tuft (GT) and the proximal tubule (PT) in the hypertrophying kidney (HK) remaining 7 days after UN in 10 rats treated with ACTH and 7 control animals. The histologic preparations were examined under light microscopy with the "Kontron" image analyzer. ACTH increased the weight of the HK (1213.8 +/- 20.3 mg versus 1037.3 +/- 13.3, p less than 0.001) and determined an enlargement of the cross sectional area of the GT (12559 +/- 3351.3 mu2 versus 10486 +/- 407.5, p less than 0.01) and of the epithelial area of the PT (1751 +/- 40.8 mu2 versus 1586 +/- 41.5, p less than 0.025). These morphometrical data are consistent with the increased Protein/DNA ratio - a marker of cellular hypertrophy - found in other rats studied under the same experimental conditions. The increased weight gain of the HK elicited by ACTH is related to the hypertrophy of the epithelial cells of the PT and possibly to an enlargement of the glomeruli. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|