Patterns and determinants of use of pharmacological therapies for intermittent claudication in PAD outpatients: results of the IDOMENEO study
| Autor: | Adriana Visonà, Claudio Cimminiello, G. Arpaia, Hernan Polo Friz, Giuseppe Marano, Patrizia Boracchi, Siapav Investigators, Gabriella Spezzigu |
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| Rok vydání: | 2016 |
| Předmět: |
Male
medicine.medical_specialty Multivariate analysis Tetrazoles 030204 cardiovascular system & hematology 03 medical and health sciences Peripheral Arterial Disease 0302 clinical medicine Risk Factors Internal medicine Outpatients medicine Humans Ankle Brachial Index 030212 general & internal medicine Prospective Studies Aged Polypharmacy Univariate analysis business.industry Intermittent Claudication Middle Aged Intermittent claudication Cilostazol Italy Multivariate Analysis Physical therapy Population study Patient Compliance Observational study Female medicine.symptom Hydroxymethylglutaryl-CoA Reductase Inhibitors Cardiology and Cardiovascular Medicine business Platelet Aggregation Inhibitors medicine.drug Cohort study |
| Zdroj: | International angiology : a journal of the International Union of Angiology. 36(3) |
| ISSN: | 1827-1839 |
| Popis: | Peripheral arterial disease (PAD) usually presents with intermittent claudication (IC). The aim of the present study was to assess, in clinical practice, the pattern of use of pharmacological therapies for IC in stable PAD outpatients.A propensity analysis was performed using data from the IDOMENEO study, an observational prospective multicenter cohort study. The association between any pharmacological symptomatic IC therapy with different variables was investigated using generalized linear mixed models with pharmacological therapy as response variable and binomial error.Study population: 213 patients, male sex 147 (69.0%), mean age 70.0±8.6 years. Only 36.6% was under pharmacological treatment for IC, being cilostazol the most used medication (21.6%). Univariate analysis showed a probability of a patient of being assigned to any pharmacological symptomatic IC therapy of 67.0% when Ankle-Brachial Index (ABI)0.6 and 29.8% when ABI0.6 (P=0.0048), and a propensity to avoid pharmacological treatment for patients with a high number of drugs to treat cardiovascular risk factors (probability of 55.2% for4 drugs and 19.6% for4 drugs, P=0.0317). Multivariate analysis confirmed a higher probability of assigning treatment for ABI0.6 (P=0.0274), and a trend to a lower probability in patients under polypharmacy (4 drugs: OR=0.13, P=0.0546).In clinical practice, only one third of stable outpatients with IC used symptomatic pharmacological therapy for IC. We found a propensity of clinicians to assign any symptomatic pharmacological IC therapy to patients with lower values of ABI and a propensity to avoid this kind of treatment in patients under polypharmacy. |
| Databáze: | OpenAIRE |
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