Regulation of sodium and calcium channels by signaling complexes
| Autor: | Xin Jiang, William A. Catterall, Joanne T. Hulme, W. Preston Few |
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| Rok vydání: | 2006 |
| Předmět: |
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Physiological Voltage-gated ion channel Voltage-dependent calcium channel Inward-rectifier potassium ion channel Chemistry Cell Biology Light-gated ion channel Biochemistry Sodium Channels Cell biology SK channel Electrophysiology Stretch-activated ion channel Multiprotein Complexes Animals Humans Calcium Channels Uniporter Molecular Biology Calcium signaling Signal Transduction |
| Zdroj: | Journal of receptor and signal transduction research. 26(5-6) |
| ISSN: | 1079-9893 |
| Popis: | Membrane depolarization and intracellular calcium transients generated by activation of voltage-gated sodium and calcium channels are local signals, which initiate physiological processes such as action potential conduction, synaptic transmission, and excitation-contraction coupling. Targeting of effector proteins and regulatory proteins to ion channels is an important mechanism to ensure speed, specificity, and precise regulation of signaling events in response to local stimuli. In this article, we review recent experimental results showing that sodium and calcium channels form local signaling complexes, in which effector proteins, anchoring proteins, and regulatory proteins interact directly with ion channels. The intracellular domains of these channels serve as signaling platforms, mediating their participation in intracellular signaling processes. These protein-protein interactions are important for efficient synaptic transmission and for regulation of ion channels by neurotransmitters and intracellular second messengers. These localized signaling complexes are essential for normal function and regulation of electrical excitability, synaptic transmission, and excitation-contraction coupling. |
| Databáze: | OpenAIRE |
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