Histopathology, cell proliferation indices and clinical outcome in 304 patients with mantle cell lymphoma (MCL): a clinicopathological study from the European MCL Network
| Autor: | Tiemann M, Schrader C, Klapper W, Dreyling MH, Campo E, Norton A, Berger F, Kluin P, Ott G, Pedrinis E, Feller AC, Merz H, Janssen D, Hansmann ML, Krieken H, Moller P, Stein H, Unterhalt M, Hiddemann W, Parwaresch R, European MCL Network, PILERI, STEFANO |
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| Přispěvatelé: | Tiemann M, Schrader C, Klapper W, Dreyling MH, Campo E, Norton A, Berger F, Kluin P, Ott G, Pileri S, Pedrinis E, Feller AC, Merz H, Janssen D, Hansmann ML, Krieken H, Moller P, Stein H, Unterhalt M, Hiddemann W, Parwaresch R, European MCL Network. |
| Rok vydání: | 2005 |
| Předmět: |
Adult
Male medicine.medical_specialty Pathology Mitotic index Age-related aspects of cancer [ONCOL 2] Genetics and epigenetic pathways of disease [NCMLS 6] Lymphoma Mantle-Cell Translational research [ONCOL 3] Internal medicine Biomarkers Tumor Mitotic Index Humans Medicine Clinical significance Prospective Studies Prospective cohort study Survival analysis Aged Cell Proliferation Retrospective Studies Molecular diagnosis prognosis and monitoring [UMCN 1.2] Aged 80 and over Clinical Trials as Topic Hematology Hereditary cancer and cancer-related syndromes [ONCOL 1] business.industry Middle Aged Prognosis medicine.disease Survival Analysis Lymphoma Ki-67 Antigen Treatment Outcome Multivariate Analysis Female Mantle cell lymphoma Histopathology business |
| Zdroj: | British Journal of Haematology, 131, 1, pp. 29-38 British Journal of Haematology, 131, 29-38 |
| ISSN: | 0007-1048 |
| Popis: | Contains fulltext : 47723.pdf (Publisher’s version ) (Closed access) Mantle cell lymphoma (MCL) is a distinct lymphoma subtype with a particularly poor clinical outcome. The clinical relevance of the morphological characteristics of these tumours remains uncertain. The European MCL Network reviewed 304 cases of MCL to determine the prognostic significance of histopathological characteristics. Cytomorphological subtypes, growth pattern and markers of proliferation (mitotic and Ki-67 indices) were analysed. In addition to the known cytological subtypes, classical (87.5%), small cell (3.6%), pleomorphic (5.9%) and blastic (2.6%), we identified new pleomorphic subgroups with mixtures of cells (classical + pleomorphic type; 1.6%) or transitions (classical/pleomorphic type; 1.6%), which, however, did not differ significantly in overall survival time. Exactly 80.5% of cases displayed a diffuse growth pattern, whereas 19.5% of cases had a nodular growth pattern, which was associated with a slightly more favourable prognosis. A high proliferation rate (mitotic or Ki-67 indices) was associated with shorter overall survival. Cut-off levels were defined that allowed three subgroups with different proliferation rates to be discriminated, which showed significantly different clinical outcomes (P < 0.0001). Based on this large clinicopathological study of prospective clinical trials, multivariate analysis confirmed the central prognostic role of cell proliferation and its superiority to all other histomorphological and clinical criteria. |
| Databáze: | OpenAIRE |
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