Spatial variation of perfusion MRI reflects cognitive decline in mild cognitive impairment and early dementia
| Autor: | Reece P. Roberts, John C. Dalrymple-Alford, Lynette J. Tippett, Tracy R. Melzer, Josef Pfeuffer, Henk J M M Mutsaerts, Nicholas J Cutfield, Donna Rose Addis, Ian J. Kirk, Catherine Morgan, Tim J. Anderson, Kristina Wiebels, Meg J. Spriggs, Gerard Deib |
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| Přispěvatelé: | Radiology and nuclear medicine |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Science Neuroimaging Grey matter Article Temporal lobe Alzheimer Disease Internal medicine medicine Dementia Humans Cognitive Dysfunction Cognitive decline Cerebral perfusion pressure Cognitive deficit Aged Spatial Analysis Multidisciplinary medicine.diagnostic_test business.industry Cognitive ageing Magnetic resonance imaging Alzheimer's disease medicine.disease medicine.anatomical_structure Cerebral blood flow Case-Control Studies Cerebrovascular Circulation Cardiology Medicine Female medicine.symptom business Biomarkers Magnetic Resonance Angiography New Zealand |
| Zdroj: | Scientific Reports Scientific Reports, 11(1):23325. Nature Publishing Group Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021) Morgan, C A, Melzer, T R, Roberts, R P, Wiebels, K, Mutsaerts, H J M M, Spriggs, M J, Dalrymple-Alford, J C, Anderson, T J, Cutfield, N J, Deib, G, Pfeuffer, J, Addis, D R, Kirk, I J & Tippett, L J 2021, ' Spatial variation of perfusion MRI reflects cognitive decline in mild cognitive impairment and early dementia ', Scientific Reports, vol. 11, no. 1, 23325 . https://doi.org/10.1038/s41598-021-02313-z |
| ISSN: | 2045-2322 |
| Popis: | Cerebral blood flow (CBF) measured with arterial spin labelling (ASL) magnetic resonance imaging (MRI) reflects cerebral perfusion, related to metabolism, and arterial transit time (ATT), related to vascular health. Our aim was to investigate the spatial coefficient of variation (sCoV) of CBF maps as a surrogate for ATT, in volunteers meeting criteria for subjective cognitive decline (SCD), amnestic mild cognitive impairment (MCI) and probable Alzheimer’s dementia (AD). Whole-brain pseudo continuous ASL MRI was performed at 3 T in 122 participants (controls = 20, SCD = 44, MCI = 45 and AD = 13) across three sites in New Zealand. From CBF maps that included all grey matter, sCoV progressively increased across each group with increased cognitive deficit. A similar overall trend was found when examining sCoV solely in the temporal lobe. We conclude that sCoV, a simple to compute imaging metric derived from ASL MRI, is sensitive to varying degrees of cognitive changes and supports the view that vascular health contributes to cognitive decline associated with Alzheimer’s disease. |
| Databáze: | OpenAIRE |
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