Morphological and topographical appearance of microaneurysms on optical coherence tomography angiography
| Autor: | Freerk G. Venhuizen, Eiko K. de Jong, B. Jeroen Klevering, Bart Liefers, Thomas Theelen, Artin Domanian, Vivian Schreur, Carel B. Hoyng |
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| Rok vydání: | 2019 |
| Předmět: |
Microaneurysm
medicine.medical_specialty Retinal thickening Capillary plexus medicine.diagnostic_test business.industry Retinal Optical coherence tomography angiography Fluorescein angiography Sensory disorders Donders Center for Medical Neuroscience [Radboudumc 12] Sensory Systems 03 medical and health sciences Cellular and Molecular Neuroscience Ophthalmology chemistry.chemical_compound All institutes and research themes of the Radboud University Medical Center 0302 clinical medicine Diabetic macular oedema chemistry 030221 ophthalmology & optometry Medicine business 030217 neurology & neurosurgery Fundus fluorescein angiography |
| Zdroj: | British Journal of Ophthalmology, 103, 630-635 British Journal of Ophthalmology, 103, 5, pp. 630-635 |
| ISSN: | 0007-1161 |
| Popis: | AimsTo investigate retinal microaneurysms in patients with diabetic macular oedema (DME) by optical coherence tomography angiography (OCTA) according to their location and morphology in relationship to their clinical properties, leakage on fundus fluorescein angiography (FFA) and retinal thickening on structural OCT.MethodsOCTA and FFA images of 31 eyes of 24 subjects were graded for the presence of microaneurysms. The topographical and morphological appearance of microaneurysms on OCTA was evaluated and classified. For each microaneurysm, the presence of focal leakage on FFA and associated retinal thickening on OCT was determined.ResultsOf all microaneurysms flagged on FFA, 295 out of 513 (58%) were also visible on OCTA. Microaneurysms with focal leakage and located in a thickened retinal area were more likely to be detected on OCTA than not leaking microaneurysms in non-thickened retinal areas (p=0.001). Most microaneurysms on OCTA were seen in the intermediate (23%) and deep capillary plexus (22%). Of all microaneurysms visualised on OCTA, saccular microaneurysms were detected most often (31%), as opposed to pedunculated microaneurysms (9%). Irregular, fusiform and mixed fusiform/saccular-shaped microaneurysms had the highest likeliness to leak and to be located in thickened retinal areas (pConclusionsRetinal microaneurysms in DME could be classified topographically and morphologically by OCTA. OCTA detected less microaneurysms than FFA, and this appeared to be dependent on leakage activity and retinal thickening. Morphological appearance of microaneurysms (irregular, fusiform and mixed saccular/fusiform) was associated with increased leakage activity and retinal thickening. |
| Databáze: | OpenAIRE |
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