Ivermectin Protects against Monosodium Glutamate-Induced Excitotoxicity in the Rat
| Autor: | Abimbola K. Arise, Oluwole I. Oyewole, Rotimi Olusanya Arise, S. O. Malomo |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Monosodium glutamate
business.industry lcsh:R monosodium glutamate Excitotoxicity lcsh:Medicine General Medicine glutamate channels Pharmacology medicine.disease_cause Body weight ivermectin chemistry.chemical_compound Ivermectin chemistry Oral administration medicine oxidative stress business excitotoxicity Oxidative stress medicine.drug |
| Zdroj: | Acta Facultatis Medicae Naissensis, Vol 36, Iss 1, Pp 38-47 (2019) |
| ISSN: | 2217-2521 |
| DOI: | 10.2478/afmnai-2019-0004 |
| Popis: | Summary Monosodium glutamate (MSG), an established excitotoxic food additive, has been found to induce oxidative stress in all tissues. To examine the protective effects of ivermectin on MSG-induced excitotoxicity, 28 male albino rats were randomized into four groups. Group 1, the control, received 1 ml of oral distilled water, group 2 was administered an aqueous solution of MSG (4 mg/kg body weight/day). Group 3 was co-administered with the same dose of MSG and 0.4 mg/kg body weight of ivermectin, while group 4 rats received orally the same dose of MSG for 2 weeks, after which ivermectin was administered orally for 1 week. Administration of MSG orally for 21 days and for 14 days, followed by oral administration of ivermectin for 7 days, significantly increased (p < 0.05) glutathione-S-transferase, nitric oxide synthase, superoxide dismutase and catalase activities as well as malondialdehyde and intracellular Ca2+ concentrations while Na+ - K+ - ATPase, Ca2+ - Mg2+ - ATPase, acid phosphatase (ACP) and alkaline phosphatase (ALP) activities were significantly reduced (p < 0.05) compared to the control. However, co-administration of MSG and ivermectin for 21 days did not show any significant difference (p > 0.05) in all the parameters studied compared to the control. This result suggests that ivermectin may protect against MSG-induced excitotoxicity in rats. |
| Databáze: | OpenAIRE |
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