Effectiveness of salvage intratympanic dexamethasone treatment for refractory sudden sensorineural hearing loss classified by audiogram patterns
| Autor: | Guohui Nie, Qingyin Zheng, Hongmiao Ren, Mo Chen, Xiaozhu Chen, Bing Hu, Jihao Ren, Duanlong Zhao |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male medicine.medical_specialty Hearing Loss Sensorineural Anti-Inflammatory Agents Intratympanic dexamethasone Audiology Dexamethasone 03 medical and health sciences 0302 clinical medicine Refractory otorhinolaryngologic diseases medicine Hearing improvement Humans 030223 otorhinolaryngology Retrospective Studies Salvage Therapy Injection Intratympanic medicine.diagnostic_test business.industry Endoscopy General Medicine Audiogram Middle Aged Treatment Outcome Otorhinolaryngology 030220 oncology & carcinogenesis Sudden sensorineural hearing loss Audiometry Pure-Tone Female Pure tone audiometry business |
| Zdroj: | Acta oto-laryngologica. 141(5) |
| ISSN: | 1651-2251 |
| Popis: | Intratympanic dexamethasone is commonly conducted to treat refractory sudden sensorineural hearing loss (RSSNHL). However, no consensus has been reached on its effectiveness.The study aimed to evaluate the effectiveness of otoendoscope-assisted salvage intratympanic dexamethasone treatment (IDT) on RSSNHL with different audiogram patterns after failure of initial therapy.A total of 108 patients with unilateral RSSNHL were classified into 4 groups according to audiogram patterns. Hearing results were evaluated by pure-tone audiometry (PTA), which was performed at baseline and one month after otoendoscope-assisted salvage IDT. The effectiveness of otoendoscope-assisted salvage IDT was assessed in each group.The efficiency in low-frequency, high-frequency, flat, and deaf group was 48%, 24.1%, 46.2%, 17.9%, respectively. The efficacy did not differ between the high-frequency and deaf group. Notably, the efficacy in the low-frequency and flat group was significantly higher than that in the deaf group.Otoendoscope-assisted salvage IDT is a safe and effective treatment for RSSNHL. This treatment provided better results for patients with low-frequency damaged and flat curve audiogram than patients with other audiogram patterns.Audiogram patterns should be considered in the clinical management of patients with RSSHNL prior to salvage IDT. |
| Databáze: | OpenAIRE |
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