Intracranial heterotransplantation of human hematopoietic cells in nude mice
| Autor: | Christa Fonatsch, Volker Diehl, Michael Schaadt, Hartmut Kirchner |
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| Rok vydání: | 1979 |
| Předmět: |
Herpesvirus 4
Human Cancer Research Pathology medicine.medical_specialty Lymphoma Transplantation Heterologous Cell Mice Nude Receptors Antigen B-Cell Biology Malignancy Virus Cell Line Mice medicine Animals Humans Neoplasm Antigens Viral Chromosome Aberrations Leukemia Hematopoietic Stem Cell Transplantation Neoplasms Experimental medicine.disease Clone Cells Transplantation Haematopoiesis medicine.anatomical_structure Oncology Cell culture Neoplasm Transplantation |
| Zdroj: | International Journal of Cancer. 23:751-761 |
| ISSN: | 1097-0215 0020-7136 |
| DOI: | 10.1002/ijc.2910230604 |
| Popis: | A panel of established cell lines and many primary cell specimens from lymphomas and leukemias as well as from normal lymphatic tissues were tested for tumorigenicity by intracranial hetero-transplantation in nude mice. Not only lymphoma and leukemia cell lines, but also lymphoblastoid cell lines, lacking markers of malignancy, were tumorigenic in the brains of nude mice. These findings indicate that tumorigenicity following intracranial heterotransplantation in nude mice cannot be used as proof for the malignant nature of established cell lines. Heterotransplantation of primary cell specimens yielded only a few tumor takes. When primary cells were infected with exogenous Epstein-Barr virus prior to the transplantation procedure, tumorigenicity could be significantly increased. Cytogenetic evaluation of tumors growing after intracranial transplantation of human hematopoietic cells showed, in some cases, a selection of cytogenetically aberrant cell clones. |
| Databáze: | OpenAIRE |
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