Identification of novel microRNAs in Rous sarcoma Virus (RSV) and their target sites in tumor suppressor genes of chicken
| Autor: | Supriyo Chakraborty, S. B. Paul, Momi Saikia |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Sarcoma
Avian Microbiology (medical) animal structures viruses Microbiology law.invention Retrovirus law microRNA Genetics medicine Animals Genes Tumor Suppressor Nucleotide Molecular Biology Gene Poultry Diseases Ecology Evolution Behavior and Systematics chemistry.chemical_classification Rous sarcoma virus biology Cancer medicine.disease biology.organism_classification MicroRNAs Infectious Diseases chemistry RNA Viral Suppressor Sarcoma Chickens |
| Zdroj: | Infection, Genetics and Evolution. 96:105139 |
| ISSN: | 1567-1348 |
| Popis: | A small non-coding, evolutionarily conserved regulatory RNA molecule known as microRNA (miRNA) regulates various cellular activities and pathways. MicroRNAs remain evolutionarily conserved in different species of same taxa. They are present in all organisms including viruses. Viral miRNAs are small, less conserved and less stable and have higher negative minimal folding free energy than miRNAs of different organisms. The size of viral precursor miRNA is approximately 60-119 nucleotides in length. The structure of the mature miRNA sequences is predicted by using higher negative MFE (ΔG) value. Rous sarcoma Virus (RSV), named after its inventor Peyton Rous, has been known for causing tumors in the chicken for which it is known as an oncogenic retrovirus. Using specific criteria we have predicted 5 potential miRNAs in RSV which targeted 8 tumor suppressor genes in Gallus gallus. This study aims to predict the potential miRNAs, secondary structures and their targets for better understanding of the regulatory network of Rous sarcoma virus miRNA in forming sarcoma. |
| Databáze: | OpenAIRE |
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