Effects of a high soy protein diet on intestinal polyamines and ornithine decarboxylase activity in rats
| Autor: | Mohammed Bouras, Robert Benamouzig, Sylvain Mahé, J. Rautureau, Karima Meziani, Daniel Tomé, Antoine Martin |
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| Přispěvatelé: | Physiologie de la Nutrition et du Comportement Alimentaire (UPNCA), Institut National de la Recherche Agronomique (INRA)-Institut National Agronomique Paris-Grignon (INA P-G) |
| Rok vydání: | 1999 |
| Předmět: |
medicine.medical_specialty
[SDV]Life Sciences [q-bio] Endocrinology Diabetes and Metabolism Clinical Biochemistry Ileum Biology Biochemistry Ornithine decarboxylase 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Intestinal mucosa Internal medicine Casein medicine Molecular Biology Soy protein ComputingMilieux_MISCELLANEOUS 030304 developmental biology 0303 health sciences Cadaverine Nutrition and Dietetics medicine.anatomical_structure Endocrinology chemistry Putrescine 030211 gastroenterology & hepatology Polyamine |
| Zdroj: | Journal of Nutritional Biochemistry Journal of Nutritional Biochemistry, Elsevier, 1999, 10 (7), pp.405-410 |
| ISSN: | 0955-2863 |
| DOI: | 10.1016/s0955-2863(99)00019-4 |
| Popis: | This study was performed to determine whether intestinal luminal polyamine concentrations are affected by a high soy protein diet when compared with a high casein diet or a normoprotein casein diet. We also determined the effects of these diets, with differences in polyamines content, on mucosal polyamines and ornithine decarboxylase (ODC) activity to assess cell proliferation. Three groups of eight male Wistar rats were fed either a 50% soy protein diet, a 50% casein diet, or an 18% casein diet as a control. After 4 weeks of feeding, both intestinal content and mucosa were recovered. Polyamines were assayed by high performance liquid chromatography. ODC activity was measured by the release of (14)CO(2) from (14)C-L-ornithine. Luminal putrescine and cadaverine concentrations were higher in the jejunum than in the ileum, suggesting an absorptive process. The highest concentrations of intestinal polyamines were observed in rats fed the soy protein diet (P0.05). Only minor differences were observed in mucosal polyamines according to the diets. ODC activity was also higher in the intestinal mucosa of rats fed the high soy protein diet (P0.05). These results suggest that intestinal luminal polyamine concentrations and ODC activity are modulated by the dietary protein source. |
| Databáze: | OpenAIRE |
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