Electrophysiological effects of nicardipine hydrochloride on the isolated sinoatrial and atrioventricular nodes of the rabbit
| Autor: | Makoto Kadoya, Shoichi Yokoyama, Chuichi Kawai, Tomotsugu Konishi, Toshitake Tamamura, Hiroko Matsuda |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
medicine.medical_specialty
Nifedipine Refractory Period Electrophysiological Physiology Refractory period Pyridines Nicardipine Pharmacology In Vitro Techniques Heart Conduction System Internal medicine Nicardipine Hydrochloride medicine Animals Sinoatrial Node Dose-Response Relationship Drug Sinoatrial node business.industry Effective refractory period Calcium Channel Blockers Atrioventricular node Endocrinology medicine.anatomical_structure Atrioventricular Node Rabbits Electrical conduction system of the heart Cardiology and Cardiovascular Medicine business Microelectrodes medicine.drug |
| Zdroj: | Japanese circulation journal. 47(7) |
| ISSN: | 0047-1828 |
| Popis: | The electrophysiological effects of nicardipine-HCl, a new calcium antagonist and potent vasodilator, were studied in the isolated sinoatrial (SA) and atrio-ventricular (AV) nodes of the rabbit in an oxygenated Tyrode solution at 35 degrees C using an intracellular microelectrode technique. Nicardipine-HCl decreased the spontaneous rate of the SA node and prolonged sinus recovery time, dose-dependently. The effective refractory period (ERP) and functional refractory period (FRP) of the AV node and AV conduction time (A-H interval) were also prolonged by nicardipine-HCl in a dose-dependent manner. In conclusion, nicardipine-HCl has electrophysiological effects on the SA and the AV node similar to those of other calcium antagonists in the excised and superfused rabbit heart. |
| Databáze: | OpenAIRE |
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