99mTc-d,l-HMPAO and SPECT of the Brain in Normal Aging
| Autor: | Palle Petersen, Allan R. Andersen, Florence Delecluse, Anni Johnsen, Gunhild Waldemar, Olaf B. Paulson, Steen G. Hasselbalch |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Adult
Male Aging Hemodynamics Single-photon emission computed tomography Technetium Tc 99m Exametazime Atrophy Cerebellum Oximes medicine Humans Aged Aged 80 and over Cerebral Cortex Tomography Emission-Computed Single-Photon medicine.diagnostic_test business.industry Cerebrum Brain Organotechnetium Compounds Blood flow Middle Aged medicine.disease Frontal Lobe medicine.anatomical_structure Neurology Positron emission tomography Cerebral cortex Cerebrovascular Circulation Female Neurology (clinical) Cardiology and Cardiovascular Medicine Nuclear medicine business Xenon Radioisotopes Emission computed tomography |
| Zdroj: | Journal of Cerebral Blood Flow & Metabolism. 11:508-521 |
| ISSN: | 1559-7016 0271-678X |
| DOI: | 10.1038/jcbfm.1991.95 |
| Popis: | Single photon emission computed tomography (SPECT) with 99mTc- d,l-hexamethylpropyleneamine oxime (99mTc- d,l-HMPAO) was used to determine global and regional CBF in 53 healthy subjects aged 21–83 years. For the whole group, global CBF normalized to the cerebellum was 86.4% ± 8.4 (SD). The contribution of age, sex, and atrophy to variations in global CBF was studied using stepwise multiple regression analysis. There was a significant negative correlation of global CBF with subjective ratings of cortical atrophy, but not with ratings of ventricular size, Evans ratio, sex, or age. In a subgroup of 33 subjects, in whom volumetric measurements of atrophy were performed, cortical atrophy was the only significant determinant for global CBF, accounting for 27% of its variance. Mean global CBF as measured with the 133Xe inhalation technique and SPECT was 54 ± 9 ml/100 g/min and did not correlate significantly with age. There was a preferential decline of CBF in the frontal cortex with advancing age. The side-to-side asymmetry of several regions of interest increased with age. A method was described for estimation of subcortical CBF, which decreased with advancing cortical atrophy. The relative area of the subcortical low-flow region increased with age. These results are useful in distinguishing the effects of age and simple atrophy from disease effects, when the 99mTc- d,l-HMPAO method is used. |
| Databáze: | OpenAIRE |
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