N‐terminal pro brain natriuretic peptide eliminates the prognostic effect of atrial fibrillation in patients with chronic heart failure
| Autor: | Hanna Fröhlich, Lutz Frankenstein, Tobias Täger, Johannes Schnorbach, Anna Corletto, Hugo A. Katus |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty lcsh:Diseases of the circulatory (Cardiovascular) system 030204 cardiovascular system & hematology NT‐proBNP 03 medical and health sciences 0302 clinical medicine Internal medicine Original Research Articles Natriuretic Peptide Brain medicine Humans Sinus rhythm 030212 general & internal medicine Original Research Article cardiovascular diseases Risk factor Aged Heart Failure Ejection fraction business.industry Hazard ratio Atrial fibrillation Middle Aged medicine.disease Prognosis Confidence interval Peptide Fragments Chronic heart failure lcsh:RC666-701 Concomitant Heart failure Chronic Disease Cardiology Female Cardiology and Cardiovascular Medicine business |
| Zdroj: | ESC Heart Failure, Vol 6, Iss 4, Pp 640-648 (2019) ESC Heart Failure |
| ISSN: | 2055-5822 |
| Popis: | Aims Co‐morbid atrial fibrillation (AF) increases both mortality and N‐terminal pro brain natriuretic peptide (NT‐proBNP) concentrations in patients with chronic heart failure (CHF). It is unclear whether AF worsens prognosis independently from NT‐proBNP concentrations. If AF was an independent risk factor, NT‐proBNP levels for outcome prediction would need to be adjusted in patients with AF. We aimed to analyse the influence of AF on the prognostic value of NT‐proBNP in patients with CHF. Methods and results A total of 2541 consecutive CHF patients with sinus rhythm (SR) or AF were identified in the outpatients' CHF registry of the University of Heidelberg, Germany. Of these, 250 patients with SR were individually matched to 250 patients with AF with respect to NT‐proBNP, New York Heart Association functional class, sex, age, and aetiology of CHF. In the general sample, both AF and NT‐proBNP were associated with all‐cause mortality [hazard ratio (HR) = 1.96, 95% confidence interval (CI) 1.61–2.39, P |
| Databáze: | OpenAIRE |
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