Phase 2 study of eribulin mesylate as first-line therapy for locally recurrent or metastatic human epidermal growth factor receptor 2-negative breast cancer
Autor: | Erhan Berrak, Linda T. Vahdat, David Cox, Stefan Glück, Joyce O'Shaughnessy, Kristi McIntyre, James Song, Lee S. Schwartzberg |
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Jazyk: | angličtina |
Předmět: |
Adult
Eribulin Mesylate Oncology medicine.medical_specialty Cancer Research Receptor ErbB-2 Antineoplastic Agents Breast Neoplasms chemistry.chemical_compound Breast cancer Triple-negative breast cancer Internal medicine medicine Adjuvant therapy Humans Eribulin Progression-free survival Neoplasm Metastasis Furans Aged Neoplasm Staging Aged 80 and over Taxane business.industry Ketones Middle Aged Metastatic breast cancer medicine.disease Clinical Trial HER2-negative breast cancer Treatment Outcome chemistry Female Neoplasm Recurrence Local business |
Zdroj: | Breast Cancer Research and Treatment |
ISSN: | 0167-6806 |
DOI: | 10.1007/s10549-014-2923-9 |
Popis: | Eribulin mesylate, a novel non-taxane microtubule dynamics inhibitor, is approved for treatment of metastatic breast cancer (MBC) in patients who have previously received at least 2 chemotherapeutic regimens for MBC that should have included an anthracycline and a taxane in the adjuvant or metastatic setting. This phase 2 study evaluated efficacy and safety of eribulin as first-line therapy for human epidermal growth factor receptor 2-negative (HER2-negative) MBC. Patients with measurable HER2-negative locally recurrent breast cancer or MBC with ≥12 months since prior neoadjuvant or adjuvant (neo/adjuvant) chemotherapy received eribulin mesylate 1.4 mg/m(2) IV on days 1 and 8 of each 3-week cycle. Endpoints included objective response rate (ORR) per RECIST v1.1 (primary), safety, progression-free survival (PFS), clinical benefit rate (ORR + stable disease ≥6 months; CBR), and duration of response (DOR). Fifty-six patients were enrolled and received eribulin; 38 (68 %) had prior neo/adjuvant therapy, including 33 who had anthracycline and/or taxane-containing chemotherapy; 41 (73 %) had estrogen receptor-positive disease, and 12 (21 %) had estrogen receptor-negative, progesterone receptor-negative, and HER2-negative (triple-negative) disease. Patients received a median of 7 cycles (range 1-43); 6 (11 %) received treatment for ≥12 months. ORR was 29 % (95 % CI 17.3-42.2), CBR was 52 %, and median DOR was 5.8 months. Median PFS was 6.8 months. Thirty-six patients (64 %) had grade 3/4 treatment-related adverse events; most common were neutropenia (50 %), leukopenia (21 %), and peripheral neuropathy (21 %). These results demonstrate that eribulin has substantial antitumor activity as first-line treatment for HER2-negative MBC with acceptable safety. |
Databáze: | OpenAIRE |
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