Fibromyalgia syndrome and cognitive dysfunction in elderly: a case series
| Autor: | Chie Usui, Kenya Nishioka, Nobuto Shibata, Tetsuo Hayashi, Ryota Tanaka, Kusuki Nishioka, Sachiko Nakayama, Takashi Matsushima, Yumiko Motoi, Yuanzhe Li, Michimasa Suzuki, Nobutaka Hattori |
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| Rok vydání: | 2015 |
| Předmět: |
Aging
medicine.medical_specialty Pediatrics Fibromyalgia Neuropsychological Tests Corpus callosum Temporal lobe 03 medical and health sciences Cognition 0302 clinical medicine Rheumatology Alzheimer Disease Surveys and Questionnaires medicine Humans Aged Pain Measurement Aged 80 and over Tomography Emission-Computed Single-Photon 030203 arthritis & rheumatology Central Nervous System Sensitization medicine.diagnostic_test business.industry Age Factors Chronic pain Brain Magnetic resonance imaging Syndrome medicine.disease Magnetic Resonance Imaging Aphasia Primary Progressive Case-Control Studies Frontotemporal Dementia Physical therapy Female Alzheimer's disease Cognition Disorders business Neurocognitive 030217 neurology & neurosurgery Frontotemporal dementia |
| Zdroj: | International Journal of Rheumatic Diseases. 19:21-29 |
| ISSN: | 1756-1841 |
| DOI: | 10.1111/1756-185x.12734 |
| Popis: | Aim Fibromyalgia syndrome (FMS) is an extremely rare complication of neurocognitive disorders (NCDs). We experienced seven such cases, and we discuss their clinical manifestation and pathomechanisms. Methods Seven patients with FMS as a complication of NCD were enrolled. We used the patients' medical records to identify clinical manifestations and obtain experimental data, such as pain questionnaire scores, cognitive tests, genetics and radiological imaging of the brain. Results The seven patients were clinically diagnosed with frontotemporal NCD (n = 3) or Alzheimer's disease (n = 4). No patient presented with any organic disorder that would explain their chronic pain. Through their courses, they experienced refractory widespread pain continuously despite analgesics. Brain magnetic resonance imaging revealed moderate or severe atrophic changes in the temporal lobes and hippocampus. Three-dimensional stereotactic surface projection (3D-SSP) analysis of brain single photon emission computed tomography (SPECT), indicated severe hypoperfusion on the right side of the medial temporal lobe, both sides of the anterior corpus callosum, anterior cingulate gyrus, and primary sensory area. Genetic analysis uncovered no pathogenic mutations. Conclusions Neurodegenerative disorders are rarely complicated by FMS, which is associated with relatively severe pain. Central sensitization may be a possible risk factor of widespread pain in elderly patients with NCD. |
| Databáze: | OpenAIRE |
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