Association of interleukin-6 and transforming growth factor-β1 gene polymorphisms with developmental hip dysplasia and severe adult hip osteoarthritis: A preliminary study
| Autor: | Vladimir Trkulja, Sandra Kraljević Pavelić, Robert Kolundžić, Krešimir Pavelić, Michele Mikolaučić, Mirna Jovanić Kolundžić |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Male medicine.medical_specialty Immunology Locus (genetics) Osteoarthritis Biology Biochemistry Osteoarthritis Hip Bone remodeling Transforming Growth Factor beta1 Pathogenesis Internal medicine Genotype medicine Humans Immunology and Allergy Allele Promoter Regions Genetic Interleukin 6 Hip Dislocation Congenital Molecular Biology DNA Primers Genetics Polymorphism Genetic Base Sequence Interleukin-6 Promoter Hematology Middle Aged medicine.disease Endocrinology biology.protein interleukin-6 transforming growth factor-β1 gene polymorphisms developmental hip dysplasia hip osteoarthritis Female Bone Remodeling Polymorphism Restriction Fragment Length |
| Zdroj: | Cytokine. 54:125-128 |
| ISSN: | 1043-4666 |
| DOI: | 10.1016/j.cyto.2011.02.004 |
| Popis: | Developmental hip dysplasia (DDH) greatly contributes to occurrence of severe hip osteoarthritis (OA) in adulthood, but the association between the two is not a perfect one. Both conditions are known to have a strong genetic component. Transforming growth factor β1 (TGF-β1) and interleukin-6 (IL-6) are two pro- inflammatory cytokines included in pathogenesis of OA, bone remodeling and development of bone and joint tissues. TGF-β1 gene has a polymorphic site in the signal sequence ((29)T→C) and "C allele carriage" is associated with higher circulating TGF-β1 levels. IL-6 gene has several polymorphic sites in the promoter region including -572T→C transition associated with higher circulating IL-6 levels. As a preliminary investigation on possible association between these polymorphisms and severe adult hip OA secondary to DDH, 28 consecutive patients and 20 healthy controls were genotyped at these loci. With adjustment for sex, "C allele carriage" in the TGF-β1 signal sequence and CC genotype ("transition homozygous") at locus -572 in the IL-6 promoter were each associated with severe OA secondary to DDH (OR=13.4, p=0.016 and OR=6.2, p=0.024, respectively). The combination of these genotypes was particularly strongly associated with the disease (OR=11.1, p |
| Databáze: | OpenAIRE |
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