Extended phenotype and clinical subgroups in unilateral Meniere disease: A cross-sectional study with cluster analysis
| Autor: | L, Frejo, E, Martin-Sanz, R, Teggi, G, Trinidad, A, Soto-Varela, S, Santos-Perez, R, Manrique, N, Perez, I, Aran, M S, Almeida-Branco, A, Batuecas-Caletrio, J, Fraile, J M, Espinosa-Sanchez, V, Perez-Guillen, H, Perez-Garrigues, M, Oliva-Dominguez, O, Aleman, J, Benitez, P, Perez, J A, Lopez-Escamez, Maria Cruz, Tapia |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male medicine.medical_specialty Time Factors Referral Cross-sectional study Hearing loss Migraine Disorders Autoimmune Diseases MENIERE DISEASE 03 medical and health sciences 0302 clinical medicine Vertigo Internal medicine medicine Cluster Analysis Humans 030223 otorhinolaryngology Hearing Loss Meniere Disease Aged Retrospective Studies biology business.industry Retrospective cohort study Middle Aged biology.organism_classification medicine.disease Surgery Clinical trial Cross-Sectional Studies Phenotype Otorhinolaryngology Migraine Female medicine.symptom business 030217 neurology & neurosurgery |
| Zdroj: | Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe instname CLINICAL OTOLARYNGOLOGY r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante |
| ISSN: | 1749-4486 1749-4478 |
| Popis: | OBJECTIVES: To define clinical subgroups by cluster analysis in patients with unilateral Meniere disease (MD) and to compare them with the clinical subgroups found in bilateral MD. DESIGN: A cross-sectional study with a two-step cluster analysis. SETTINGS: A tertiary referral multicenter study. PARTICIPANTS: Nine hundred and eighty-eight adult patients with unilateral MD. MAIN OUTCOME MEASURES: best predictors to define clinical subgroups with potential different aetiologies. RESULTS: We established five clusters in unilateral MD. Group 1 is the most frequently found, includes 53% of patients, and it is defined as the sporadic, classic MD without migraine and without autoimmune disorder (AD). Group 2 is found in 8% of patients, and it is defined by hearing loss, which antedates the vertigo episodes by months or years (delayed MD), without migraine or AD in most of cases. Group 3 involves 13% of patients, and it is considered familial MD, while group 4, which includes 15% of patients, is linked to the presence of migraine in all cases. Group 5 is found in 11% of patients and is defined by a comorbid AD. We found significant differences in the distribution of AD in clusters 3, 4 and 5 between patients with uni- and bilateral MD. CONCLUSIONS: Cluster analysis defines clinical subgroups in MD, and it extends the phenotype beyond audiovestibular symptoms. This classification will help to improve the phenotyping in MD and facilitate the selection of patients for randomised clinical trials. |
| Databáze: | OpenAIRE |
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