Critical Material Attributes of Strip Films Loaded With Poorly Water-Soluble Drug Nanoparticles: II. Impact of Polymer Molecular Weight
| Autor: | Rajesh N. Dave, Ecevit Bilgili, Scott M. Krull, Meng Li, Sonia Bawa, Jennifer Ammirata |
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| Rok vydání: | 2017 |
| Předmět: |
Thermogravimetric analysis
Antifungal Agents Materials science Pharmaceutical Science Nanoparticle 02 engineering and technology 030226 pharmacology & pharmacy Griseofulvin 03 medical and health sciences Viscosity Hypromellose Derivatives 0302 clinical medicine Tensile Strength Ultimate tensile strength Polymer chemistry chemistry.chemical_classification Aqueous solution Water Polymer 021001 nanoscience & nanotechnology Biopharmaceutics Classification System Biodegradable polymer Drug Liberation Solubility chemistry Chemical engineering Nanoparticles 0210 nano-technology |
| Zdroj: | Journal of Pharmaceutical Sciences. 106:619-628 |
| ISSN: | 0022-3549 |
| DOI: | 10.1016/j.xphs.2016.10.009 |
| Popis: | Recent work established polymer strip films as a robust platform for delivery of poorly water-soluble drug particles. However, a simple means of manipulating rate of drug release from films with minimal impact on film mechanical properties has yet to be demonstrated. This study explores the impact of film-forming polymer molecular weight (MW) and concentration on properties of polymer films loaded with poorly water-soluble drug nanoparticles. Nanoparticles of griseofulvin, a model Biopharmaceutics Classification System class II drug, were prepared in aqueous suspension via wet stirred media milling. Aqueous solutions of 3 viscosity grades of hydroxypropyl methylcellulose (14, 21, and 88 kDa) at 3 viscosity levels (∼9500, ∼12,000, and ∼22,000 cP) were mixed with drug suspension, cast, and dried to produce films containing griseofulvin nanoparticles. Few differences in film tensile strength or elongation at break were observed between films within each viscosity level regardless of polymer MW despite requiring up to double the time to achieve 100% drug release. This suggests film-forming polymer MW can be used to manipulate drug release with little impact on film mechanical properties by matching polymer solution viscosity. In addition, changing polymer MW and concentration had no negative impact on drug content uniformity or nanoparticle redispersibility. |
| Databáze: | OpenAIRE |
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