Diagnostic role of cytology in serous effusions of patients with hematologic malignancies
| Autor: | Penelope Korkolopoulou, Nikolitsa Kafasi, Panagiota Mikou, Maria K. Angelopoulou, T.P. Vassilakopoulos, Konstantinos Konstantopoulos, Kyriaki Savvidou, Aglaia Dimitrakopoulou, Panagiotis Kanavaros, Marina P. Siakantaris |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male medicine.medical_specialty Histology Lymphoma 030209 endocrinology & metabolism Diagnostic accuracy Pathology and Forensic Medicine 03 medical and health sciences 0302 clinical medicine Cytology medicine Hematologic malignancy Ascitic Fluid Humans Aged Leukemia business.industry Clinical performance General Medicine Middle Aged Flow Cytometry Predictive value Pleural Effusion Serous fluid Hematologic Neoplasms 030220 oncology & carcinogenesis Pericardial Fluid Female Radiology business |
| Zdroj: | Diagnostic Cytopathology. 47:404-411 |
| ISSN: | 1097-0339 8755-1039 |
| Popis: | Background We investigated serous effusions occurring during the course of an already known hematologic neoplasia or as a first manifestation of it. We correlated cytology results with flow cytometry results, when available. In the absence of flow cytometry, our correlation was based on clinical follow up information obtained retrospectively. We evaluated our results in relation to the data of the literature and we considered some new suggestions for the improvement of cytology service. Methods Serous effusions in hematologic patients were retrieved from the files of the Department of Cytology, Laiko Hospital, for a period of 2 years. All patients had enrolled either a previous hematologic history, or a suspicious clinical and imaging status. Seventy-three serous effusions were included. Cytology reports consisting of morphology and immunocytochemistry assessment were correlated to flow cytometry results and, occasionally, to clinical follow-up. Results In the group of patients with previous history, sensitivity was 82.76%, positive predictive value was 100%, specificity 100%, and negative predictive value was 58.33%. In the group of patients without previous history, sensitivity and positive predictive value were both 91%, whereas specificity and negative predictive value could not be estimated. Conclusion We provide evidence that the diagnostic accuracy of cytology with the adjunct of immunocytochemistry is high compared to flow cytometry for detecting hematologic malignancies. In order to improve clinical performance, it is suggested that a cytology triage of serous effusions in all patients with hematologic malignancy must be implemented. |
| Databáze: | OpenAIRE |
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