Risk of hypercalcemia in patients with very high serum 25‐OH vitamin D levels
| Autor: | Esra Cil Sen, Emre Sedar Saygili, Yuksel Altuntas, Adnan Batman, Feyza Yener Ozturk, Duygu Yildiz, Rumeysa Selvinaz Erol, Muhammed Masum Canat |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male medicine.medical_specialty chemistry.chemical_element ORIGINAL PAPERS 030204 cardiovascular system & hematology Calcium Gastroenterology vitamin D deficiency 03 medical and health sciences 0302 clinical medicine Interquartile range Internal medicine Vitamin D and neurology Humans Medicine In patient 030212 general & internal medicine Vitamin D Inverse correlation Aged Original Paper business.industry High serum General Medicine Middle Aged Vitamin D Deficiency medicine.disease Calcium Dietary chemistry Parathyroid Hormone Metabolism & Endocrinology Hypercalcemia Alkaline phosphatase Female business |
| Zdroj: | International Journal of Clinical Practice |
| ISSN: | 1742-1241 1368-5031 |
| DOI: | 10.1111/ijcp.14181 |
| Popis: | Objective We aimed to evaluate the risk of hypercalcemia in patients with very high levels of 25‐hydroxy vitamin D (25(OH)D). Methods The distribution of patients who were screened for 25(OH)D in our hospital between January 2014 and December 2018 was evaluated and patients with serum concentrations of 25(OH)D >88 ng/mL were selected. Then, biochemical parameters of the cases with 25(OH)D >88 ng/mL were compared according to calcium status, vitamin D level (group 1, 88‐100 ng/mL; group 2, 100‐150 ng/mL, and group 3, >150 ng/mL), and gender. Results A total of 282 932 patients who underwent 25(OH)D tests in our hospital were evaluated. A total of 1311 (0.5%) patients had very high 25(OH)D levels (>88 ng/mL). Four hundred and ninety‐five patients who met our inclusion criteria and had complete data participated in the study. The median age was 58 years (interquartile range [IQR] = 41‐71 years) and the median level of 25(OH)D was 104.6 mg/mL (IQR = 94.9‐124.9 ng/mL). Most of the subjects (83.7%) with very high 25(OH)D levels were normocalcemic. A weak inverse correlation was observed between 25(OH)D level and intact parathyroid hormone (iPTH) level (r = −0.118, P = .01), but no correlation between 25(OH)D and calcium levels was observed. Alkaline phosphatase (ALP) levels were significantly higher in males (P = .032), and age and iPTH levels were higher in females (P |
| Databáze: | OpenAIRE |
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