Liver injury after aluminum potassium sulfate and tannic acid treatment of hemorrhoids

Autor: Yuki Hirose, Hiroyuki Kijima, Keiko Shibata, Kenichi Yoshikawa, Akira Iwaku, Hirohiko Kobayashi, Masayuki Saruta, Nami Imai, Takafumi Akasu, Akiyoshi Kinoshita, Kazuhiko Koike, Go Kobayashi, Nao Fushiya, Reimi Kawashima, Noriko Hagiwara, Takeharu Yokota
Rok vydání: 2017
Předmět:
Adult
Male
medicine.medical_specialty
Lidocaine
Fever
Drug-induced lymphocyte stimulation test
Drug-induced liver injury
Rectum
Case Report
Aluminum potassium sulfate and tannic acid injection
Injections
Intralesional
Aluminum potassium sulfate and tannic acid therapy
Gastroenterology
Hemorrhoids
Liver disorder
03 medical and health sciences
Rectal submucosal injection
0302 clinical medicine
Postoperative Complications
Liver Function Tests
Internal medicine
Submucosa
Sclerotherapy
medicine
Humans
Liver injury
business.industry
General Medicine
medicine.disease
Anus
Sclerosing Solutions
medicine.anatomical_structure
Liver
030220 oncology & carcinogenesis
Internal Hemorrhoid
Alum Compounds
030211 gastroenterology & hepatology
Chemical and Drug Induced Liver Injury
business
Tannins
medicine.drug
Zdroj: World Journal of Gastroenterology
ISSN: 2219-2840
Popis: We are reporting a rare case of acute liver injury that developed after an internal hemorrhoid treatment with the aluminum potassium sulfate and tannic acid (ALTA) regimen. A 41-year-old man developed a fever and liver injury after undergoing internal hemorrhoid treatment with a submucosal injection of ALTA with lidocaine. The acute liver injury was classified clinically as hepatocellular and pathologically as cholestastic. We could not classify the mechanism of injury. High eosinophil and immunoglobulin E levels characterized the injury, and a drug lymphocyte stimulation test was negative on postoperative day 25. Fluid replacement for two weeks after hospitalization improved the liver injury. ALTA therapy involves injecting chemicals into the submucosa, from the rectum to the anus, and this is the first description of a case that developed a severe liver disorder after this treatment; hence, an analysis of future cases as they accumulate is desirable.
Databáze: OpenAIRE
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