Galectin-9 regulates T helper cell function independently of Tim-3
| Autor: | Lawrence P. Kane, Shuguang Bi, Ee W Su |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Galectins
Biochemistry Mice Interleukin 21 Immune system otorhinolaryngologic diseases medicine Animals Humans Cytotoxic T cell Receptor Hepatitis A Virus Cellular Receptor 2 Cells Cultured Galectin Mice Knockout biology Communication T-Lymphocytes Helper-Inducer T helper cell Eosinophil Cell biology Mice Inbred C57BL stomatognathic diseases medicine.anatomical_structure biology.protein Cytokines Receptors Virus Antibody |
| Zdroj: | Glycobiology. 21:1258-1265 |
| ISSN: | 1460-2423 0959-6658 |
| Popis: | β-Galactoside-binding lectin 9 (galectin-9) is a tandem repeat-type member of the galectin family. It was initially characterized as an eosinophil chemoattractant and an inducer of apoptosis in thymocytes. Subsequently, galectin-9 was identified as a ligand for transmembrane immunoglobulin mucin domain 3 (Tim-3), a type I glycoprotein induced on T cells during chronic inflammation. Work in autoimmune diseases and chronic viral infections have led to the current hypothesis that the function of Tim-3 is to limit immune responses. However, it is still not known to what degree these effects are due to the galectin-9/Tim-3 interaction. In this study, we show that galectin-9 is not limited to the role of a pro-apoptotic agent, but that it can also induce the production of pro-inflammatory cytokines from T helper cells. This effect is dose-dependent and does not require Tim-3. These findings suggest that the effects of galectin-9 on T cells are more complex than previously thought and are mediated by additional receptors apart from Tim-3. |
| Databáze: | OpenAIRE |
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