Therapeutic effects of EGF-modified curcumin/chitosan nano-spray on wound healing
| Autor: | Ping Zhou, Huan Shi, XianLun Pang, QingQing Leng, Ling Zhao, ShaoZhi Fu, YanLin Liu, SuSu Xiao, Yue Li |
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| Rok vydání: | 2020 |
| Předmět: |
wound healing
02 engineering and technology Pharmacology Biomaterials Chitosan 03 medical and health sciences chemistry.chemical_compound In vivo Epidermal growth factor skin regeneration Medicine curcumin 030304 developmental biology EGF Skin repair 0303 health sciences integumentary system business.industry Therapeutic effect 021001 nanoscience & nanotechnology chemistry Drug delivery Curcumin AcademicSubjects/SCI01410 chitosan 0210 nano-technology business Wound healing AcademicSubjects/MED00010 Research Article |
| Zdroj: | Regenerative Biomaterials |
| ISSN: | 2056-3418 |
| Popis: | Dermal injury, including trauma, surgical incisions, and burns, remain the most prevalent socio-economical health care issue in the clinic. Nanomedicine represents a reliable administration strategy that can promote the healing of skin lesions, but the lack of effective drug delivery methods can limit its effectiveness. In this study, we developed a novel nano-drug delivery system to treat skin defects through spraying. We prepared curcumin-loaded chitosan nanoparticles modified with epidermal growth factor (EGF) to develop an aqueous EGF-modified spray (EGF@CCN) for the treatment of dermal wounds. In vitro assays showed that the EGF@CCN displayed low cytotoxicity, and that curcumin was continuously and slowly released from the EGF@CCN. In vivo efficacy on wound healing was then evaluated using full-thickness dermal defect models in Wistar rats, showing that the EGF@CCN had significant advantages in promoting wound healing. On day 12 post-operation, skin defects in the rats of the EGF@CCN group were almost completely restored. These effects were related to the activity of curcumin and EGF on skin healing, and the high compatibility of the nano formulation. We therefore conclude that the prepared nano-scaled EGF@CCN spray represents a promising strategy for the treatment of dermal wounds. |
| Databáze: | OpenAIRE |
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