Developmental toxicity and risk assessment of nonylphenol to the South American toad, Rhinella arenarum
| Autor: | Aronzon Carolina Mariel, Babay Paola Alejandra, Pérez Coll Cristina Silvia |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Embryo
Nonmammalian Time Factors Otras Ciencias Biológicas Health Toxicology and Mutagenesis Developmental toxicity Zoology AMPHIBIANS Toad Toxicology Risk Assessment Lethal Dose 50 purl.org/becyt/ford/1 [https] chemistry.chemical_compound Phenols biology.animal Animals Bioassay STAGE-DEPENDENT SUSCEPTIBILITY purl.org/becyt/ford/1.6 [https] TERATOGENESIS Pharmacology Larva biology Embryo General Medicine biology.organism_classification Nonylphenol NONYLPHENOL Teratogens EMBRYO-LARVAL DEVELOPMENT chemistry Rhinella arenarum Toxicity Bufo arenarum CIENCIAS BIOLÓGICAS Environmental Pollutants CIENCIAS NATURALES Y EXACTAS |
| Zdroj: | Environmental Toxicology and Pharmacology, 2014 38(2): 634-642 Elsevier Science Bv Repositorio Institucional (UNSAM) Universidad Nacional de General San Martín instacron:UNSAM CONICET Digital (CONICET) Consejo Nacional de Investigaciones Científicas y Técnicas instacron:CONICET |
| DOI: | 10.1016/j.etap.2014.08.014 |
| Popis: | The toxicity of Nonylphenol, an emerging pollutant, on the common South American toad Rhinella arenarum was stage and time dependent, thus Median Lethal Concentrations (LC50) for acute (96 h), short-term chronic (168 h) and chronic exposure (336 h) were 1.06; 0.96 and 0.17 mgNP/L from embryonic period (S.4), whereas for exposure from larvae (S.25), LC50 remained constant at 0.37 mgNP/L from 96 h to 168 h, decreasing to 0.11 mgNP/L at 336 h. NOEC-168 h for exposure from embryos was 0.025 mgNP/L. The Teratogenic Potential (NOEC-lethality/NOEC-sublethal effects) was 23 times higher than the threshold value, indicating a high risk for embryos to be malformed in absence of significant lethality and representing a threat for the species conservation. By comparing with other amphibians, the early development of R. arenarum was very sensitive to NP. The results highlight the relevance of extending the exposure time and look for the most sensitive stage in order to perform the bioassays for conservation purposes. Fil: Aronzon, Carolina Mariel. Universidad Nacional de San Martín. Instituto de Investigación e Ingeniería Ambiental; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Babay, Paola Alejandra. Comisión Nacional de Energía Atómica; Argentina Fil: Perez Coll, Cristina Silvia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de San Martín. Instituto de Investigación e Ingeniería Ambiental; Argentina |
| Databáze: | OpenAIRE |
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