Intra-articular sodium hyaluronate injections in the osteoarthritic ankle joint: Effects, safety and dose dependency
| Autor: | Inger N. Sierevelt, Leendert Blankevoort, Gino M. M. J. Kerkhoffs, Angelique G.H. Witteveen, C. Niek van Dijk |
|---|---|
| Přispěvatelé: | Other departments, Orthopedic Surgery and Sports Medicine, Amsterdam Movement Sciences, Biomedical Engineering and Physics, Other Research |
| Rok vydání: | 2010 |
| Předmět: |
Adult
Male medicine.medical_specialty Sodium hyaluronate Walking Osteoarthritis Drug Administration Schedule Injections Intra-Articular law.invention Young Adult chemistry.chemical_compound Randomized controlled trial law Arthropathy medicine Humans Single-Blind Method Orthopedics and Sports Medicine Longitudinal Studies Prospective Studies Hyaluronic Acid Prospective cohort study Aged Pain Measurement Aged 80 and over Dose-Response Relationship Drug Viscosupplements business.industry Middle Aged medicine.disease Surgery Regimen medicine.anatomical_structure chemistry Female Viscosupplementation Ankle business Ankle Joint |
| Zdroj: | Foot and ankle surgery, 16(4), 159-163. Elsevier Limited |
| ISSN: | 1268-7731 1460-9584 |
| DOI: | 10.1016/j.fas.2009.10.003 |
| Popis: | Background To determine the efficacy, safety and dose dependency of intra-articular Orthovisc ® hyaluronic acid injections in the ankle. Methods A prospective single blinded study in patients with symptomatic ankle–osteoarthritis. Patients were randomly allocated to 1, 2, 3ml, or 3 weekly injections of 1ml (3× 1ml). Primary outcome was ‘pain during walking' at 15 weeks measured on a 100mm VAS. Results Twenty-six patients (ITT) participated. The 3× 1ml dose group showed statistically significant decreases at week 7 for ‘pain during walking' and ‘pain at rest' ( p =0.046). At week 15 decreases were significant for ‘pain at rest' ( p =0.046). There was no significant decrease of VAS-scores in any of the single dose groups. Seven patients experienced temporary local swelling and increased pain in the injected ankle. Conclusions Orthovisc ® viscosupplementation in the ankle joint is effective and well tolerated. The 3× 1ml dose regimen shows the best results. |
| Databáze: | OpenAIRE |
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