In vitro models for investigation of the host-parasite interface - possible applications in acute Chagas disease
| Autor: | Juliana Lott Carvalho, Mariana Hecht, Nadjar Nitz, Ester Rose, Natalia Martins Breyner |
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| Přispěvatelé: | ToxAlim (ToxAlim), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Ecole d'Ingénieurs de Purpan (INPT - EI Purpan), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), University of Brasilia [Brazil] (UnB), Universidade Católica de Brasília (UCB), Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior - Brasil (CAPES) Finance Code 001, Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq: 421897/2016-3), and Fundacao de Apoio a Pesquisa do Distrito Federal) (FAPDF): 193.001.471/2017. |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Chagas disease Trypanosoma cruzi Veterinary (miscellaneous) [SDV]Life Sciences [q-bio] 030231 tropical medicine Translational research Disease Host-Parasite Interactions 03 medical and health sciences 0302 clinical medicine Pluripotent stem cells In vivo medicine Animals Humans Parasite hosting Cells Cultured biology In vitro models 030108 mycology & parasitology medicine.disease biology.organism_classification In vitro 3. Good health Organoids Infectious Diseases Insect Science Parasitic disease Immunology Parasitology [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology |
| Zdroj: | Acta Tropica Acta Tropica, Elsevier, 2020, 202, ⟨10.1016/j.actatropica.2019.105262⟩ |
| ISSN: | 0001-706X |
| DOI: | 10.1016/j.actatropica.2019.105262⟩ |
| Popis: | Chagas disease (CD), caused by Trypanosoma cruzi, is the main parasitic disease in the Western Hemisphere, with an increasing number of cases, especially in non-endemic regions. The disease is characterized by cardiomegaly and mega viscera, nevertheless, the clinical outcome is hard to predict, underscoring the need for further research into the pathophysiology of CD. Even though most basic and translational research involving CD is performed using in vivo models, in vitro models arise as an ethical, rapidly evolving, and physiologically relevant alternative for CD research. In the present review, we discuss the past and recent in vitro models available to study the host-parasite interface in cardiac and intestinal CD, critically analyzing the possibilities and limitations of state-of-the-art alternatives for the CD host-parasite investigation. |
| Databáze: | OpenAIRE |
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