Frequent adverse events after treatment for childhood-onset differentiated thyroid carcinoma: a single institute experience
| Autor: | H.M. van Santen, T. Vulsma, Doron Aronson, R.F.H.M Tummers, C. van den Bos, J. J. M. De Vijlder, M.M. Geenen |
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| Přispěvatelé: | Other departments, Paediatric Surgery, Paediatric Endocrinology, CCA -Cancer Center Amsterdam, APH - Amsterdam Public Health, Paediatric Oncology |
| Rok vydání: | 2004 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Pediatrics Adolescent Hypoparathyroidism Iodine Radioisotopes Thyroid carcinoma Risk Factors Adenocarcinoma Follicular medicine Paralysis Carcinoma Humans Survivors Thyroid Neoplasms Child Adverse effect Thyroid cancer Lymph node business.industry Mortality rate medicine.disease Carcinoma Papillary Surgery medicine.anatomical_structure Oncology Child Preschool Recurrent Laryngeal Nerve Injuries Thyroidectomy Female Neoplasm Recurrence Local medicine.symptom business Follow-Up Studies |
| Zdroj: | European journal of cancer (Oxford, England, 40(11), 1743-1751. Elsevier Limited |
| ISSN: | 0959-8049 |
| Popis: | Since the mortality rate for childhood differentiated thyroid carcinoma is nearly zero, the focus must be to minimise morbidity following treatment. Our aim was to analyse early and late adverse events. Twenty-five of 26 children treated between 1962 and 2002 were evaluated. Median follow-up was 14.2 years (range 0.9-39.4 years). All underwent total thyroidectomy, 15 (60%) with lymph node dissection and 15 (60%) with adjuvant radio-iodide therapy. Mortality was zero. Seven developed recurrent disease, two developed a third recurrence. Twenty-one (84%) had greater than or equal to1 adverse event. Eight had permanent hypoparathyroidism (PH), six permanent recurrent nerve paralysis (PRNP) and two Horner's syndrome. Risk factors for PH and PRNP were total thyroidectomy with lymph node dissection (RR: 6.45, P = 0.0 15) and recurrent nerve tumour encasement (RR: 8.00, P = 0.001), respectively. Other adverse events were fatigue (n = 5), scar problems (n = 4) and chronic myeloid leukaemia (n = 1). These results emphasise the need to improve treatment strategies. (C) 2004 Elsevier Ltd. All rights reserved |
| Databáze: | OpenAIRE |
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