Interleukin-6 gene promoter –174G/C polymorphism and insulin resistance: a pilot study
| Autor: | Antra Jurka, Peteris Tretjakovs, Inga Bormane, Gustavs Latkovskis, Dace Juhnevica, Valdis Pirags, Juris Imants Aivars, N. Licis, Agnis Stifts |
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| Rok vydání: | 2007 |
| Předmět: |
Male
medicine.medical_specialty Genotype medicine.medical_treatment Clinical Biochemistry Coronary Disease Pilot Projects Biology chemistry.chemical_compound Insulin resistance Risk Factors Polymorphism (computer science) Internal medicine medicine Humans Obesity Promoter Regions Genetic Pancreatic hormone Aged Polymorphism Genetic Triglyceride Interleukin-6 Insulin Cholesterol HDL Biochemistry (medical) Age Factors nutritional and metabolic diseases General Medicine Middle Aged medicine.disease Endocrinology chemistry Cardiovascular Diseases Female Insulin Resistance Body mass index |
| Zdroj: | Clinical Chemical Laboratory Medicine. 45 |
| ISSN: | 1437-4331 1434-6621 |
| Popis: | Background: The aim of this pilot study was to evaluate the relationship between interleukin-6 promoter -174G/C (IL-6 -174G/C) polymorphism and insulin resistance (IR) in obese patients with coronary heart disease (CHD). Methods: Twenty obese male patients with CHD were selected from a larger database of patients (n=606). IL-6 -174G/C genotype was previously analysed and only homozygotes with the CC genotype (n=10) or GG genotype (n=10) were selected. IR was measured using the homeostasis model assessment for IR (HOMA-IR) method. Results: Differences in age, body mass index, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol (HDL-C), triglyceride (TG), hypertension, IL-6, C-reactive protein and HOMA-IR were not significant between the genotypes (p>0.05), but analysis of a homogeneity-of-slopes model showed that genotype had a significant influence on HOMA-IR (p= 0.037), and the interaction between genotype and HDL-C had a pronounced tendency to affect HOMA-IR (p=0.058). Using multiple regression analysis, we found that HDL-C had a significant effect on HOMA-IR (p= 0.023), and TG had a tendency to affect HOMA-IR (p=0.066) only in the CC genotype. Conclusions: Our data show that IL-6 -174G/C polymorphism may have a significant effect on IR. A comparison between the effects of various cardiovascular risk factors showed that HDL-C may have a significant effect on HOMA-IR in the CC genotype but not in the GG genotype. Further research is needed to test the preliminary results. |
| Databáze: | OpenAIRE |
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