Effects of psychotropic drugs on the distribution of 3H-dopamine into compartments of rat striatal synaptosomes and on subsequent depolarization-induced 3H-dopamine release
| Autor: | Arie H. Mulder, de Langen Cd |
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| Rok vydání: | 1980 |
| Předmět: |
Drug
Nomifensine Reserpine Dopamine media_common.quotation_subject Pharmacology toxicology Tyramine In Vitro Techniques Pharmacology chemistry.chemical_compound Cocaine medicine Animals Distribution (pharmacology) Neurotransmitter media_common Psychotropic Drugs Depolarization General Medicine Corpus Striatum Rats chemistry Potassium Efflux Synaptosomes medicine.drug |
| Zdroj: | Naunyn-Schmiedeberg's Archives of Pharmacology. 311:169-177 |
| ISSN: | 1432-1912 0028-1298 |
| DOI: | 10.1007/bf00510256 |
| Popis: | The effects of various drugs on the distribution of 3H-dopamine in rat striatal synaptosomes were studied after superfusion with this radiolabelled neurotransmitter. By compartmental analysis of the efflux of radioactivity, drug effects on the total accumulation of 3H-dopamine, on the “bound fraction” and on the rate constant of the efflux of radioactivity from the tissue were determined. Subsequently, the synaptosomes were exposed to 40 mM K+, in order to assess also the effects of these drugs on depolarization-induced 3H-dopamine release. The results show that: It is concluded that with the approach used in the present study, a relable distinction between uptake-inhibiting and releasing effects of drugs can be made. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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