Beneficial effects of sublingual nifedipine in patients with ischemic heart disease and depressed left ventricular function
| Autor: | John P. Wexler, Anthony A. Losardo, William H. Frishman, Joel A. Strom, Nusen Beer, Neal Klein, Edmund H. Sonnenblick |
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| Rok vydání: | 1982 |
| Předmět: |
Male
Mean arterial pressure medicine.medical_specialty Nifedipine Pyridines Heart Ventricles Administration Oral Blood Pressure Coronary Disease Disease 030226 pharmacology & pharmacy Coronary artery disease 03 medical and health sciences 0302 clinical medicine Heart Rate Internal medicine Heart rate medicine Humans Myocardial infarction Cardiac Output Radionuclide Imaging Ejection fraction Ventricular function business.industry Stroke Volume Middle Aged medicine.disease Stimulation Chemical 030220 oncology & carcinogenesis Anesthesia Cardiology Female Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | Angiology. 33(12) |
| ISSN: | 0003-3197 |
| Popis: | The effects of sublingual nifedipine, a calcium channel beta-blocking drug, were assessed in eleven patients with coronary artery disease and depressed left ventricular function. All patients had a previous documented myocardial infarction. Specifically examined were the effects of a 20 mg dose on left ventricular ejection fraction as assessed through gated pool nuclear imaging. All patients had their anti-anginal drugs stopped forty-eight hours prior to inclusion in the study. Baseline resting determinations included a mean heart rate of 80 beats/minute, mean arterial pressure of 97 mmHg and an ejection fraction of 36 percent. Thirty minutes following a 20 mg sublingual dose, these parameters were reassessed. Mean heart rate increased to 89 beats/minute, p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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