Cyclohexadepsipeptides from the insect pathogenic fungus Hirsutella nivea BCC 2594
| Autor: | Kanlayanee Sriklung, Kanokarn Kocharin, Somporn Palasarn, Masahiko Isaka |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Hirsutella
Plasmodium falciparum Drug Resistance Pharmaceutical Science Biology Hydrolysate Analytical Chemistry Microbiology Hemiptera Antimalarials Inhibitory Concentration 50 Depsipeptides Drug Discovery Chlorocebus aethiops Animals Nuclear Magnetic Resonance Biomolecular Vero Cells Pharmacology chemistry.chemical_classification Molecular Structure Organic Chemistry Biological activity Fungi imperfecti Mycobacterium tuberculosis Pathogenic fungus biology.organism_classification Thailand Cyclic peptide Complementary and alternative medicine chemistry Hypocreales Molecular Medicine Bacteria |
| Zdroj: | Journal of natural products. 68(11) |
| ISSN: | 0163-3864 |
| Popis: | Two new cyclohexadepsipeptides, hirsutatins A (1) and B (2), were isolated from a culture filtrate of the insect pathogenic fungus Hirsutella nivea BCC 2594. Structures of these compounds were elucidated primarily by NMR and mass spectroscopic analyses. The alpha-carbon stereochemistry of 1 was established by HPLC analysis of its acid hydrolysate using a chiral column. Hirsutatin B (2) exhibited activity against the malarial parasite Plasmodium falciparum K1 with an IC50 value of 5.8 microg/mL, while hirsutatin A (1) was inactive at a concentration of 20 microg/mL. |
| Databáze: | OpenAIRE |
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