Importance of delta opioid receptors in maintaining high alcohol drinking
| Autor: | Janice C. Froehlich, J. Harts, L. Lumeng, M. Zweifel, Ting-Kai Li |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Male
Thiorphan Alcohol Drinking Enkephalin medicine.drug_class Narcotic Antagonists Drinking Behavior Poison control (+)-Naloxone Pharmacology δ-opioid receptor chemistry.chemical_compound Opioid receptor Receptors Opioid delta Animals Medicine Enkephalinase inhibitor Ethanol Phenylpropionates Naloxone business.industry Rats chemistry Opioid Receptors Opioid Neprilysin business Enkephalin Leucine medicine.drug |
| Zdroj: | Psychopharmacology. 103:467-472 |
| ISSN: | 1432-2072 0033-3158 |
| DOI: | 10.1007/bf02244246 |
| Popis: | We have previously reported that naloxone, a nonspecific opioid receptor antagonist, suppresses alcohol but not water consumption by male rats that have been genetically selected for high voluntary alcohol drinking. However, the identity of the specific opioid receptor subtype that may mediate alcohol drinking is not known. This paper reports that a selective delta opioid receptor antagonist is as effective as naloxone in suppressing alcohol consumption and that an enkephalinase inhibitor, which potentiates the action of endogenous enkephalins, increases alcohol intake. These results suggest that alcohol-induced activation of the endogenous enkephalinergic system, and occupation of delta opioid receptors, are involved in the maintenance of continued alcohol drinking. |
| Databáze: | OpenAIRE |
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