Reduced Cortical Activity Impairs Development and Plasticity after Neonatal Hypoxia Ischemia
| Autor: | Grace Or, Hannah C. Glass, Cristopher M. Niell, Eric Y. Wang, Sumudu Ranasinghe, Peter K. H. Wong, Patrick S. McQuillen, Aiva Ievins, Joseph Sullivan, Merritt A. McLean, Vann Chau |
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| Rok vydání: | 2015 |
| Předmět: |
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Infant Mortality Electroencephalography Low Birth Weight and Health of the Newborn Medical and Health Sciences Child Development Pregnancy Subplate 2.1 Biological and endogenous factors Prospective Studies Aetiology Cerebral Cortex Pediatric Neuronal Plasticity medicine.diagnostic_test General Neuroscience Rehabilitation Glutamate receptor Brain Articles Mental Health medicine.anatomical_structure Cerebral cortex Hypoxia-Ischemia Brain Neurological Female medicine.symptom Psychology Reproductive Health and Childbirth Ischemia ischemia Basic Behavioral and Social Science neonatal Preterm Hypoxia-Ischemia Behavioral and Social Science Neuroplasticity medicine Animals Humans Rats Long-Evans Asphyxia Neurology & Neurosurgery hypoxia activity Psychology and Cognitive Sciences Infant Newborn Neurosciences Long-Evans Infant Perinatal Period - Conditions Originating in Perinatal Period Hypoxia (medical) Newborn medicine.disease Perinatal - Birth - Preterm Rats Brain Disorders Good Health and Well Being Animals Newborn Vibrissae plasticity subplate Neuroscience |
| Zdroj: | Ranasinghe, S; Or, G; Wang, EY; Ievins, A; McLean, MA; Niell, CM; et al.(2015). Reduced cortical activity impairs development and plasticity after neonatal hypoxia ischemia. Journal of Neuroscience, 35(34), 11946-11959. doi: 10.1523/JNEUROSCI.2682-14.2015. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/32m4d45d The Journal of neuroscience : the official journal of the Society for Neuroscience, vol 35, iss 34 |
| ISSN: | 1529-2401 0270-6474 |
| Popis: | UnlabelledSurvivors of preterm birth are at high risk of pervasive cognitive and learning impairments, suggesting disrupted early brain development. The limits of viability for preterm birth encompass the third trimester of pregnancy, a "precritical period" of activity-dependent development characterized by the onset of spontaneous and evoked patterned electrical activity that drives neuronal maturation and formation of cortical circuits. Reduced background activity on electroencephalogram (EEG) is a sensitive marker of brain injury in human preterm infants that predicts poor neurodevelopmental outcome. We studied a rodent model of very early hypoxic-ischemic brain injury to investigate effects of injury on both general background and specific patterns of cortical activity measured with EEG. EEG background activity is depressed transiently after moderate hypoxia-ischemia with associated loss of spindle bursts. Depressed activity, in turn, is associated with delayed expression of glutamate receptor subunits and transporters. Cortical pyramidal neurons show reduced dendrite development and spine formation. Complementing previous observations in this model of impaired visual cortical plasticity, we find reduced somatosensory whisker barrel plasticity. Finally, EEG recordings from human premature newborns with brain injury demonstrate similar depressed background activity and loss of bursts in the spindle frequency band. Together, these findings suggest that abnormal development after early brain injury may result in part from disruption of specific forms of brain activity necessary for activity-dependent circuit development.Significance statementPreterm birth and term birth asphyxia result in brain injury from inadequate oxygen delivery and constitute a major and growing worldwide health problem. Poor outcomes are noted in a majority of very premature ( |
| Databáze: | OpenAIRE |
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