COVID-19 in pediatric kidney transplantation: The Improving Renal Outcomes Collaborative
| Autor: | Nancy Rodig, Lara Danziger-Isakov, David B. Kershaw, Patricia L. Weng, Judith Sebestyen VanSickle, Samhar I. Al-Akash, Laurie Smith, Debora Matossian, Rouba Garro, Corina Nailescu, Hiren P. Patel, Shiran Chen, Jens Goebel, Charles D. Varnell, David K. Hooper, Cozumel S. Pruette, Saritha Ranabothu, Paul Fadakar, Craig W. Belsha, Michael E. Seifert, Abanti Chaudhuri, Caroline Gluck, Gina Marie Barletta, Chunyan Liu, Paul Brakeman, Lyndsay A. Harshman, Jodi M. Smith |
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| Rok vydání: | 2021 |
| Předmět: |
infection and infectious agents
medicine.medical_specialty pediatrics infectious disease kidney transplantation/nephrology Disease clinical research/practice Asymptomatic Internal medicine Epidemiology Humans Immunology and Allergy Medicine Pharmacology (medical) Prospective Studies Child Prospective cohort study Kidney transplantation Transplantation Inpatient care SARS-CoV-2 business.industry Incidence Incidence (epidemiology) COVID-19 Original Articles health services and outcomes research medicine.disease Kidney Transplantation Respiratory failure Original Article epidemiology medicine.symptom business |
| Zdroj: | American Journal of Transplantation |
| ISSN: | 1600-6135 |
| DOI: | 10.1111/ajt.16501 |
| Popis: | There are limited data on the impact of COVID-19 in children with a kidney transplant (KT). We conducted a prospective cohort study through the Improving Renal Outcomes Collaborative (IROC) to collect clinical outcome data about COVID-19 in pediatric KT patients. Twenty-two IROC centers that care for 2732 patients submitted testing and outcomes data for 281 patients tested for SARS-CoV-2 by PCR. Testing indications included symptoms and/or potential exposures to COVID-19 (N = 134, 47.7%) and/or testing per hospital policy (N = 154, 54.8%). Overall, 24 (8.5%) patients tested positive, of which 15 (63%) were symptomatic. Of the COVID-19-positive patients, 16 were managed as outpatients, six received non-ICU inpatient care and two were admitted to the ICU. There were no episodes of respiratory failure, allograft loss, or death associated with COVID-19. To estimate incidence, subanalysis was performed for 13 centers that care for 1686 patients that submitted all negative and positive COVID-19 results. Of the 229 tested patients at these 13 centers, 10 (5 asymptomatic) patients tested positive, yielding an overall incidence of 0.6% and an incidence among tested patients of 4.4%. Pediatric KT patients in the United States had a low estimated incidence of COVID-19 disease and excellent short-term outcomes. |
| Databáze: | OpenAIRE |
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