Ketogenic Diet Based on Extra Virgin Coconut Oil Has No Effects in Young Wistar Rats With Pilocarpine-Induced Epilepsy
| Autor: | Jaqueline A. Galvão, Isabelle Tenório Melo, Nassib Bezerra Bueno, Euclides Marinho Trindade-Filho, R Cyro Cabral‐Jr., Elisabete M. Rêgo, Tacy S. Machado, Tâmara Kelly de Castro Gomes, Suzana Lima de Oliveira, Terezinha da Rocha Ataíde |
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| Rok vydání: | 2018 |
| Předmět: |
Cocos
Male 0301 basic medicine medicine.medical_specialty food.ingredient medicine.medical_treatment Total frequency Status epilepticus Biochemistry Soybean oil 03 medical and health sciences Epilepsy 0302 clinical medicine food Internal medicine medicine Animals Rats Wistar 030109 nutrition & dietetics business.industry Organic Chemistry Coconut oil Pilocarpine Cell Biology medicine.disease Rats Endocrinology Cocos nucifera Coconut Oil medicine.symptom Diet Ketogenic business 030217 neurology & neurosurgery medicine.drug Ketogenic diet |
| Zdroj: | Lipids. 53:251-254 |
| ISSN: | 0024-4201 |
| Popis: | This study evaluated the effects of a ketogenic diet (KD) based on extra virgin coconut oil (Cocos nucifera L., VCO), on the treatment of epileptic rats. Two sets of experiments were conducted. First, male Wistar rats underwent induction of status epilepticus (SE) with the administration of pilocarpine intraperitoneally 21 animals reached spontaneous recurrent seizures (SRS) and were randomly allocated to the dietary regimens and video-monitored for 19 days. In the second experiment, 24 animals were randomized immediately after the induction of SE and followed for 67 days. Diets were as follows: Control (AIN-93G; 7% lipid), KetoTAGsoya (KD based on soybean oil; 69.79% lipid), and KetoTAGcoco (KD based on VCO; 69.79% lipid). There were no differences in the latency to the first crisis, total frequency, and duration of the SRS between groups in 2 experiments. The data suggest no effects of KD, with or without VCO, in rats with pilocarpine-induced epilepsy. |
| Databáze: | OpenAIRE |
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