Prognostic significance of oestrogen receptor alpha (ERα) and beta (ERβ), progesterone receptor A (PR-A) and B (PR-B) in endometrial carcinomas
| Autor: | Christian Schindlbeck, Doris Mayr, Sandra Schulze, Udo Jeschke, Christina Kuhn, Ioannis Mylonas, Klaus Friese, Naim Shabani, Susanne Kunze, Harald Sommer, Franz Willgeroth, Darius Dian, Andrea Gingelmaier |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Cancer Research medicine.medical_specialty Progesterone receptor A Estrogen receptor Biology Endometrium Internal medicine Progesterone receptor Biomarkers Tumor medicine Adjuvant therapy Estrogen Receptor beta Humans Receptor Aged Neoplasm Staging Aged 80 and over Analysis of Variance Endometrial cancer Estrogen Receptor alpha Cancer Middle Aged medicine.disease Immunohistochemistry Endometrial Neoplasms Endocrinology medicine.anatomical_structure Oncology Cancer research Female Receptors Progesterone |
| Zdroj: | European Journal of Cancer. 43:2434-2444 |
| ISSN: | 0959-8049 |
| DOI: | 10.1016/j.ejca.2007.08.014 |
| Popis: | The expression of the classic steroid receptors ERalpha and PR-A has been correlated with stage, histological grade and survival in endometrial cancer. Endometrial cancer samples (293) were immunohistochemically analysed with monoclonal antibodies against the four steroid receptors. The loss of ERalpha, PR-A and PR-B resulted in a poorer survival in endometrial cancer patients, while ERbeta expression did not demonstrate any correlations with several analysed clinicopathological characteristics and did not affect survival. Additionally, multivariate survival analysis demonstrated that PR-B was a significant independent prognostic factor for cause-specific survival. In contrast, although ERalpha and PR-A showed a significant association between different endometrial histological subtypes and grading, both receptors were not independent factors with survival in endometrial carcinoma patients. Therefore, the PR-B immunostaining might be used as an easy, simple and highly efficient marker to identify high-risk patients and may aid in the selection of patients for a more aggressive adjuvant therapy. |
| Databáze: | OpenAIRE |
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