Variation in the argyrophil cell population of the rectum in ulcerative colitis and adenocarcinoma
| Autor: | Ann Gledhill, Stephen Howe, Michael E. Enticott |
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| Rok vydání: | 1986 |
| Předmět: |
Male
medicine.medical_specialty Pathology Silver Muscularis mucosae Rectosigmoid Colon Population Enteroglucagon Adenocarcinoma Gastroenterology Pathology and Forensic Medicine Internal medicine Humans Medicine Intestinal Mucosa education education.field_of_study Staining and Labeling Rectal Neoplasms business.industry Rectum Middle Aged Hyperplasia medicine.disease Ulcerative colitis digestive system diseases Dysplasia Colitis Ulcerative Female business |
| Zdroj: | The Journal of Pathology. 149:287-291 |
| ISSN: | 1096-9896 0022-3417 |
| DOI: | 10.1002/path.1711490404 |
| Popis: | Longstanding ulcerative colitis predisposes to carcinoma of the colon. Argyrophil cell hyperplasia has been observed in association with dysplasia and neoplasia in ulcerative colitis. As the argyrophil cell population includes those cells producing enteroglucagon, a hormone thought to stimulate mucosal proliferation, this study was designed to determine whether there was any consistent variation in the argyrophil cell population in longstanding ulcerative colitis. Argyrophil cells were demonstrated by the Grimelius method of silver impregnation in sections of non-tumour bearing mucosa from the rectosigmoid colon of normal bowel, ulcerative colitics with and without tumour, and mucosa adjacent to, and distant from, carcinoma arising in otherwise normal bowel. Cell numbers were expressed as ratios of argyrophil cells per crypt, per mm of epithelium, and per mm of underlying muscularis mucosae. There was marked individual variation within all groups in all parameters. Between groups, the only significant difference was an increase in argyrophil cells per crypt in ulcerative colitis. The significance of this finding is discussed. |
| Databáze: | OpenAIRE |
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