Effects of pro‐depressant and immunomodulatory drugs on biases in decision‐making in the rat judgement bias task
| Autor: | Roberto Arban, Emma S J Robinson, Bastian Hengerer, JM Bartlett, Claire A. Hales |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
cognition
medicine.medical_specialty Tetrabenazine Judgement emotion Audiology Immunomodulating Agents Judgment 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Bias Rimonabant Corticosterone medicine Animals 030304 developmental biology 0303 health sciences major depressive disorder animal model General Neuroscience Neuropsychology Interferon-alpha Cognition neuropsychological medicine.disease Rats Mood disorders chemistry Major depressive disorder Psychology 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Hales, C A, Bartlett, J M, Arban, R, Hengerer, B & Robinson, E S 2021, ' Effects of pro-depressant and immunomodulatory drugs on biases in decision-making in the rat judgement bias task ', European Journal of Neuroscience . https://doi.org/10.1111/ejn.15127 |
| ISSN: | 1460-9568 0953-816X |
| DOI: | 10.1111/ejn.15127 |
| Popis: | Studies in human and non‐human species suggest that decision‐making behaviour can be biased by affective state, also termed an affective bias. To study these behaviours in non‐human species, judgement bias tasks have been developed. Animals are trained to associate specific cues (tones) with a positive or negative/less positive outcome. Animals are then presented with intermediate ambiguous cues and affective biases quantified by observing whether animals make more optimistic or more pessimistic choices. Here we use a high versus low reward judgement bias task and test whether pharmacologically distinct compounds, which induce negative biases in learning and memory, have similar effects on decision‐making: tetrabenazine (0.0‐1.0mg/kg), retinoic acid (0.0‐ 10.0mg/kg) and rimonabant (0.0‐10.0mg/kg). We also tested immunomodulatory compounds: interferon‐α (0‐ 100units/kg), lipopolysaccharide (0.0‐10.0μg/kg) and corticosterone (0.0‐10.0mg/kg). We observed no specific effects in the judgement bias task with any acute treatment except corticosterone which induced a negative bias. We have previously observed a similar lack of effect with acute but not chronic psychosocial stress and so next tested decision‐making behaviour following chronic interferon‐alpha. Animals developed a negative bias which was sustained even after treatment was ended. These data suggest that decision‐making behaviour in the task is sensitive to chronic but not acute effects of most pro‐depressant drugs or immunomodulators, but exogenous administration of acute corticosterone induces pessimistic behaviour. This work supports our hypothesis that biases in decision‐making develop over a different temporal scale to those seen with learning and memory which may be relevant in the development and perpetuation of mood disorders. |
| Databáze: | OpenAIRE |
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