Choriocapillaris Vascular Density Changes: Healthy vs. Advanced Exudative Age-Related Macular Degeneration Previously Treated with Multiple Anti-VEGF Intravitreal Injections
Autor: | Stanislao Rizzo, Francesco Faraldi, Raphael Kilian, Maria Cristina Savastano, Alfonso Savastano, Carmela Grazia Caputo, Gloria Gambini, Daniela Bacherini, Clara Rizzo, Benedetto Falsini, Umberto De Vico |
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Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
Medicine (General)
medicine.medical_specialty Visual acuity genetic structures Clinical Biochemistry Article Neovascularization R5-920 innovative biotechnologies Ophthalmology Statistical significance advanced exudative AMD medicine age-related macular degeneration Anti vegf Retina business.industry Settore MED/30 - MALATTIE APPARATO VISIVO OCT angiography biomarkers personalized medicine Macular degeneration Exudative age-related macular degeneration medicine.disease eye diseases medicine.anatomical_structure macular neovascularization sense organs medicine.symptom Previously treated business |
Zdroj: | Diagnostics Volume 11 Issue 11 Diagnostics, Vol 11, Iss 1958, p 1958 (2021) |
ISSN: | 2075-4418 |
Popis: | Purpose: To assess choriocapillaris vascular density (VD) in healthy and advanced exudative age-related macular degeneration (ae-AMD) patients by new full-range optical coherence tomography angiography (OCT-A). Method: In this observational, cross-sectional study, 21 healthy and 21 ae-AMD eyes, already treated with anti-VEGF, were enrolled. Angio-View retina patterns centered on fovea (6.4 × 6.4 mm) were acquired for all participants using Solix full-range OCT (Optovue Inc., Freemont, CA, USA). The main outcome was to compare choriocapillaris VD between healthy and ae-AMD eyes. Automated measurements of whole image choriocapillaris VD (%) and fovea grid-based (%) were collected for the analysis. Angio-View patterns were used to assess the flow area (mm2) of macular neovascularization (MNV) by contour flow measure algorithm. Best-corrected visual acuity (BCVA) of both groups was also used for the statistical analysis. Results: The mean age was 60.9 (±8.3) in healthy and 73.33 (±15.05) in ae-AMD eyes. The mean BCVA (ETDRS letters) was 98.47 (±1.50) in healthy and 7.04 (±5.96) in ae-AMD eyes. The Mann–Whitney test comparing choriocapillaries VD for whole and fovea healthy and ae-AMD eyes showed statistical significance (p < 0.0001 (t = 4.91 df = 40) and p < 0.0001 (t = 6.84 df = 40), respectively). Regarding, the correlation between MNV and VD of choriocapillaries, neither whole nor fovea areas were statistically significant (F = 0.38 (R2 = 0.01) and 1.68 (R2 = 0.08), respectively). Conclusions: Choriocapillaris VD showed a statistically significant reduction in comparison to healthy eyes in ae-AMD eyes. Choriocapillaris impairment can be seen in the early phase of MNV pathogenesis. |
Databáze: | OpenAIRE |
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