Anemia and neutropenia in a case of copper deficiency: role of copper in normal hematopoiesis
| Autor: | Junji Nishimura, Yasunobu Abe, Yuji Yufu, Hiroshi Ideguchi, Tsukuru Umemura, Hajime Nawata, Nobuhisa Hirase, Shingo Sadamura, Koichiro Muta |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
medicine.medical_specialty
Neutropenia Time Factors Anemia chemistry.chemical_element Gastroenterology Postgastrectomy Syndromes hemic and lymphatic diseases Internal medicine medicine Humans Aged biology business.industry Bone Marrow Examination Hematology General Medicine medicine.disease Copper Hematopoiesis Haematopoiesis medicine.anatomical_structure Parenteral nutrition chemistry Immunology biology.protein Female Parenteral Nutrition Total Bone marrow Copper deficiency Ceruloplasmin business |
| Zdroj: | Acta haematologica. 87(4) |
| ISSN: | 0001-5792 |
| Popis: | We present a patient who developed severe anemia and neutropenia after receiving parenteral nutrition for 2.5 years. The serum levels of copper and ceruloplasmin were low, and the bone marrow showed the presence of ringed sideroblasts and vacuolated immature cells. The administration of copper chloride by bolus injection led to a rapid improvement in anemia and neutropenia. The number of progenitor cells (colony-forming unit-granulocyte-macrophage and erythrocyte) present before the copper supplementation was well preserved. It is therefore suggested that copper enzymes play an important role in the maturation of hematopoietic cells. |
| Databáze: | OpenAIRE |
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