A new adenosine subtype-1 receptor antagonist, FK-838, attenuates salt-induced hypertension in dahl salt-sensitive rats*
| Autor: | Atsushi Numabe, Nobuhito Hirawa, Yukari Kawabata, Hiroshi Nagoshi, Teruhiko Toyo-oka, Tomoko Gomi, Masao Omata, Yoshio Uehara, Atsuo Goto, Hiroshi Kaneko |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
medicine.medical_specialty
Pyridines medicine.drug_class Blood Pressure Sodium Chloride Kidney Kidney Function Tests Plasma renin activity Adenosine A1 receptor chemistry.chemical_compound Internal medicine Internal Medicine medicine Animals Antihypertensive Agents Aldosterone business.industry Body Weight Rats Inbred Strains Organ Size Receptor antagonist Adenosine Adenosine receptor Rats Hydrochlorothiazide Endocrinology medicine.anatomical_structure Blood pressure Purinergic P1 Receptor Antagonists chemistry Creatinine Hypertension Eicosanoids Pyrazoles business medicine.drug |
| Zdroj: | American Journal of Hypertension. 8:1189-1199 |
| ISSN: | 0895-7061 |
| DOI: | 10.1016/0895-7061(95)00253-7 |
| Popis: | We investigated the effects of the adenosine type-1 receptor antagonist FK-838 on salt-induced hypertension in Dahl-Sea salt-sensitive (Dahl S) rats. Dahl S rats fed a high-salt (4% NaCl) diet for 4 weeks were treated with FK-838 or hydrochlorothiazide for 4 weeks and alterations in kidney function and morphologic changes were assessed. FK-838 attenuated the development of hypertension in Dahl S rats, and caused a decrease in aortic weight in a dose dependent fashion. The adenosine antagonist did not produce any detectable metabolic disturbance. The blood pressure reduction by FK-838 was associated with attenuation of glomerular and arterial injury in the kidney. The renal protective effect of FK-838 treatment was associated with a reduction of plasma renin activity and plasma aldosterone concentration. In contrast, the thiazide diuretic, which produced almost the same blood pressure reduction as FK-838, did not attenuate renal damage. These data indicate that adenosine A1 receptor antagonism reduces salt-induced hypertension and the consequent renal injuries. |
| Databáze: | OpenAIRE |
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