Monocytosis and a Low Lymphocyte to Monocyte Ratio Are Effective Biomarkers of Ulcerative Colitis Disease Activity
| Autor: | Steven Polyak, Dominic J. Cirillo, Cynthia Cherfane, Luke Gessel, Miriam B. Zimmerman |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Adolescent Leukocytosis Lymphocyte Severity of Illness Index Inflammatory bowel disease Article Monocytes Young Adult Monocytosis medicine Humans Immunology and Allergy Lymphocytes Colitis Child Aged Retrospective Studies business.industry Monocyte Gastroenterology Case-control study Middle Aged Prognosis medicine.disease Ulcerative colitis medicine.anatomical_structure ROC Curve Case-Control Studies Immunology Biomarker (medicine) Colitis Ulcerative Female business Biomarkers Follow-Up Studies |
| Zdroj: | Inflammatory Bowel Diseases. 21:1769-1775 |
| ISSN: | 1078-0998 |
| Popis: | BACKGROUND Current biomarkers in ulcerative colitis (UC) are limited by their performance, cost, and limited availability in daily practice. This study examined alterations in the leukocyte profiles as biomarkers of UC activity, including the effects of age, gender, and medications. METHODS Case-control study that included 110 UC subjects, 75 subjects with Clostridium difficile infection, and 75 non-inflammatory bowel disease (IBD) subjects, randomly selected from a single-institution IBD database. Mean values of neutrophils (N), lymphocytes (L), monocytes (M) and their ratios were compared between groups. Receiver operator curve analyses assessed the performance of each biomarker in discriminating disease states. Subgroup analyses examined leukocytes profiles with endoscopic activity. RESULTS Elevated monocyte counts and decreased L/M values significantly differed between subjects with active UC and UC in remission and performed better than the other leukocyte profiles. A monocyte count of 483 and L/M ratio of 3.1 were 60% sensitive and had a specificity of 61% and 53%, respectively for active UC. Monocyte count >860 and L/M value |
| Databáze: | OpenAIRE |
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