Deiodinases and the Three Types of Thyroid Hormone Deiodination Reactions
| Autor: | Giorgio Iervasi, Cristina Del Seppia, Laura Sabatino, Cristina Vassalle |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Thyroid Hormones
Endocrinology Diabetes and Metabolism Deiodinase DIO2 Review Article Iodide Peroxidase Diseases of the endocrine glands. Clinical endocrinology Endocrinology medicine Homeostasis Humans Hypoxia Thyroid Triiodothyronine Deiodinases biology Chemistry Euthyroid sick syndromes medicine.disease RC648-665 Cell biology medicine.anatomical_structure Oxidative stress Iodothyronine deiodinase biology.protein Polymorphisms Hormone Euthyroid sick syndrome Signal Transduction |
| Zdroj: | Endocrinology and Metabolism Endocrinology and Metabolism, Vol 36, Iss 5, Pp 952-964 (2021) |
| ISSN: | 2093-5978 2093-596X |
| Popis: | Thyroid hormone (TH) signaling is strictly regulated by iodothyronine deiodinase activity, which both preserves the circulating levels of the biologically active triiodothyronine (T3) and regulates TH homeostasis at the local level, in a cell- and time-dependent manner. Three deiodinases have been identified—namely iodothyronine deiodinase 1 (DIO1), DIO2, and DIO3—that differ in their catalytic properties and tissue distribution. The deiodinases represent a dynamic system that changes in the different stages of life according to their functions and roles in various cell types and tissues. Deiodinase activity at the tissue level permits cell-targeted fine regulation of TH homeostasis, mediating the activation (DIO1 and DIO2) and inactivation (DIO3) of THs. Deiodinase homeostasis is the driving force that leads T3-target cells towards customized TH signaling, which takes into account both the hormonal circulating levels and the tissue-specific response. This review analyzes the complex role of deiodinases in physiological and pathological contexts, exploring new challenges and opportunities deriving from a deeper knowledge of the dynamics underlying their roles and functions. |
| Databáze: | OpenAIRE |
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