Two cases of seborrheic keratosis with basal clear cells
| Autor: | Tetsunori Kimura, Takashi Anan, Takaya Fukumoto |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Male
Seborrheic keratosis medicine.medical_specialty Pathology High molecular weight cytokeratin Melanoma in situ Dermoscopy Dermatology General Medicine Biology medicine.disease 030207 dermatology & venereal diseases 03 medical and health sciences Basal (phylogenetics) 0302 clinical medicine 030220 oncology & carcinogenesis medicine Humans Immunohistochemistry Female Histopathology Keratosis Seborrheic Aged |
| Zdroj: | The Journal of Dermatology. 44:339-342 |
| ISSN: | 0385-2407 |
| Popis: | Seborrheic keratosis with basal clear cells (SKBCC) is an extremely rare histopathological variant of seborrheic keratosis that has histological similarities to melanoma in situ. We herein report two cases of SKBCC and provide the first description of the dermoscopic features of this condition, in addition to the histopathological findings. Both of the two lesions showed typical histological architectures of seborrheic keratosis with rows or focal clusters of monomorphic clear cells with abundant pale cytoplasm and small round nucleus in the basal layer. Immunohistochemical examination revealed that most clear cells were positive for high molecular weight cytokeratin (34βE12) in a peripheral pattern but were negative tor Melan-A. Dermoscopy revealed typical features of ordinary seborrheic keratosis, while unfortunately did not reflect the presence of basal clear cells. |
| Databáze: | OpenAIRE |
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