Wearable electrochemical glove-based sensor for rapid and on-site detection of fentanyl
| Autor: | Abbas Barfidokht, Joseph Wang, Rajesh Seenivasan, Lee J. Hubble, Shuyang Liu, Drew A. Hall, Rupesh K. Mishra |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
On-site drug screening
Spectrum analyzer Synthetic opioid Wireless transmission Computer science Wearable computer Optical Physics 02 engineering and technology 010402 general chemistry Multiwalled carbon 01 natural sciences Article Analytical Chemistry Fentanyl Glove based-sensor Materials Chemistry medicine Electrochemical sensors Electrical and Electronic Engineering Instrumentation Sensors business.industry Electrochemical Metals and Alloys SwIPe Materials Engineering 021001 nanoscience & nanotechnology Condensed Matter Physics Emergency situations 0104 chemical sciences Surfaces Coatings and Films Electronic Optical and Magnetic Materials Opioids body regions Good Health and Well Being 0210 nano-technology business Computer hardware medicine.drug |
| Zdroj: | Sens Actuators B Chem |
| Popis: | Rapid, on-site detection of fentanyl is of critical importance, as it is an extremely potent synthetic opioid that is prone to abuse. Here we describe a wearable glove-based sensor that can detect fentanyl electrochemically on the fingertips towards decentralized testing for opioids. The glove-based sensor consists of flexible screen-printed carbon electrodes modified with a mixture of multiwalled carbon nanotubes and a room temperature ionic liquid, 4-(3-butyl-1-imidazolio)-1-butanesulfonate. The sensor shows direct oxidation of fentanyl in both liquid and powder forms with a detection limit of 10 μM using square-wave voltammetry. The “Lab-on-a-Glove” sensors, combined with a portable electrochemical analyzer, provide wireless transmission of the measured data to a smartphone or tablet for further analysis. The integrated sampling and sensing methodology on the thumb and index fingers, respectively, enables rapid screening of fentanyl in the presence of a mixture of cutting agents and offers considerable promise for timely point-of-need screening for first responders. Such a glove-based “swipe, scan, sense, and alert” strategy brings chemical analytics directly to the user's fingertips and opens new possibilities for detecting substances of abuse in emergency situations. |
| Databáze: | OpenAIRE |
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