Association of low plasma antioxidant levels with all-cause mortality and coronary events in healthy middle-aged men from France and Northern Ireland in the PRIME study
Autor: | Gareth J. McKay, Vanina Bongard, Philippe Amouyel, Gerry Linden, Natalie Lyner, K. Fred Gey, Marie Moitry, Frank Kee, Christopher Patterson, Jean Ferrières, Jean Dallongeville, Katia Biasch, Jayne V. Woodside |
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Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
Male
Premature mortality medicine.medical_treatment Medicine (miscellaneous) Physiology Coronary Disease Northern Ireland Lower risk Vitamin Antioxidants chemistry.chemical_compound High-density lipoprotein SDG 3 - Good Health and Well-being Risk Factors Diabetes mellitus Medicine Humans Carotenoid Nutrition and Dietetics Cholesterol business.industry Retinol Vitamin E Incidence (epidemiology) Original Contribution Middle Aged medicine.disease Cardiovascular disease Blood pressure chemistry France Antioxidant business Body mass index |
Zdroj: | European Journal of Nutrition McKay, G J, Lyner, N, Linden, G J, Kee, F, Moitry, M, Biasch, K, Amouyel, P, Dallongeville, J, Bongard, V, Ferrières, J, Gey, K F, Patterson, C C & Woodside, J V 2020, ' Association of low plasma antioxidant levels with all-cause mortality and coronary events in healthy middle-aged men from France and Northern Ireland in the PRIME study ', European Journal of Nutrition . https://doi.org/10.1007/s00394-020-02455-2 |
ISSN: | 1436-6215 1436-6207 |
Popis: | Background The main underlying risk factors associated with coronary heart disease (CHD) are modifiable and oxidative injury and systemic inflammatory damage represent key aetiological factors associated with the development and progression of CHD and premature mortality. Objective To examine associations of plasma antioxidant status with all-cause mortality and fatal or non-fatal cardiovascular events. Design The PRIME study prospectively evaluated 9709 men aged 50–59 years between 1991 and 1993 in Northern Ireland and France who were free of CHD at recruitment and followed annually for deaths and cardiovascular events for 10 years. Serum concentrations of vitamin C, retinol, two forms of vitamin E (α- and γ-tocopherol) and six carotenoids were quantified by high-performance liquid chromatography. Baseline conventional risk factors were considered, as well as socioeconomic differences and lifestyle behaviours including diet, smoking habit, physical activity, and alcohol consumption through Cox regression analyses. Results At 10 years, there were 538 deaths from any cause and 440 fatal or non-fatal cardiovascular events. After adjustment for country, age, systolic blood pressure, diabetes, body mass index, cholesterol, high density lipoprotein cholesterol, triglycerides, height, total physical activity, alcohol consumption and smoking habit, higher levels of all antioxidants were associated with significantly lower risk of all-cause mortality, with the exception of γ-tocopherol. Only retinol was significantly associated with decreased risk of cardiovascular events in a fully adjusted model. Conclusions Low antioxidant levels contribute to the gradient of all-cause mortality and cardiovascular incidence independent of lifestyle behaviours and traditional cardiovascular and socioeconomic risk factors. |
Databáze: | OpenAIRE |
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