Expression of circulating micro-RNAs in hypertensive patients with left ventricular hypertrophy
| Autor: | Soh Zi Ling, Wang Chee Woon, Wong Chew Ming, Chee Kok Han |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_specialty
business.industry lcsh:Public aspects of medicine Public Health Environmental and Occupational Health lcsh:RA1-1270 Left ventricular hypertrophy medicine.disease Phenotype Mirna expression Internal medicine Cardiac hypertrophy microRNA Meeting Abstract Cardiology Medicine business Mouse Heart |
| Zdroj: | BMC Public Health BMC Public Health, Vol 12, Iss Suppl 2, p A34 (2012) |
| ISSN: | 1471-2458 |
| Popis: | Background Left ventricular hypertrophy (LVH) is a common presentation among hypertensive patients. Micro-RNAs (miRNAs) have been proven to show reproducible dysregulations in hypertrophied cardiac tissues. Three miRNAs, miR-133, miR-155, and miR-195 were used in the study to elucidate the miRNA expression anomaly in heart diseases. MiR-133 and miR-195 have been reported as two highly expressed miRNAs in normal mouse heart tissue. The aim of this study is to observe the relationship of the levels of circulating miR-133, miR-155 and miR-195, with the phenotype of cardiac hypertrophy among LVH patients and normal controls. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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